PMID: 8855487Jan 1, 1996Paper

Therapeutic modulation of free radical-mediated reperfusion injury of the liver and its surgical implications

Surgery Today
S Marubayashi, K Dohi

Abstract

It is well known that ischemia causes functional and structural damage to liver cells, and that the status of energy metabolism provides an important means of assessing the functional viability of the ischemic organ. However, the specific sequence leading to ischemic liver cell injury is not yet fully understood; therefore, it is clinically and pathophysiologically important to elucidate the mechanism of cellular injury during hepatic ischemia and subsequent reperfusion. Whereas the conventional view attributes this injury process to the ischemia itself, recent studies have demonstrated that a variable but often substantial proportion of this injury is caused by reactive oxygen metabolites that are generated at the time of reperfusion. This article presents an outline of the mechanism of cellular injury caused during hepatic ischemia and subsequent reperfusion resulting from certain types of surgery, with special reference to the xanthine-xanthine oxidase system and the activation of neutrophils and macrophages.

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Citations

Feb 28, 2001·Antioxidants & Redox Signaling·J F Engelhardt
Oct 21, 2011·Journal of Gastroenterology and Hepatology·Takashi MasudaSeigo Kitano
May 11, 2005·Kidney International·Satoshi SuzukiSeiichi Matsuo
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Feb 3, 2005·Transplantation Proceedings·K K TsinariA G Tzakis
Jan 1, 2008·Phytotherapy Research : PTR·Ozer SehirliGöksel Sener

Related Concepts

Metazoa
Free Radicals
Liver
Macrophage Activation
Xanthine Oxidase
Xanthines
Reperfusion Injury
Leukocyte Adhesion Molecules
Transplantation of Liver
Reactive Oxygen Species

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