Therapeutic nanoparticles penetrate leaves and deliver nutrients to agricultural crops

Scientific Reports
Avishai KarnyAvi Schroeder

Abstract

As the world population grows, there is a need for efficient agricultural technologies to provide global food requirements and reduce environmental toll. In medicine, nanoscale drug delivery systems grant improved therapeutic precision by overcoming biological barriers and enhancing drug targeting to diseased tissues. Here, we loaded nanoscale drug-delivery systems with agricultural nutrients, and applied them to the leaves of tomato plants. We show that the nanoparticles - liposomes composed of plant-derived lipids, penetrate the leaf and translocate in a bidirectional manner, distributing to other leaves and to the roots. The liposomes were then internalized by the plant cells, where they released their active ingredient. Up to 33% of the applied nanoparticles penetrated the leaf, compared to less than one percent of free-molecules applied in a similar manner. In our study, tomato plants treated with liposomes loaded with Fe and Mg overcame acute nutrient deficiency which was not treatable using ordinary agricultural nutrients. Furthermore, to address regulatory concerns regarding airborne nanoparticles, we rationally designed liposomes that were stable only over short spraying distances (less than 2 meters), while the liposo...Continue Reading

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Citations

Jan 31, 2020·Nanoscale·Eleanor Spielman-SunGregory V Lowry
Jun 14, 2019·Frontiers in Bioengineering and Biotechnology·Ilaria SanzariAlfredo Ambrosone
Oct 30, 2019·Critical Reviews in Biotechnology·Paola FincheiraOlga Rubilar
Jun 10, 2020·Scientific Reports·Elisheva SassonLiron Klipcan
Aug 28, 2020·Nanomaterials·Luis A ParamoKaren Esquivel
Jun 7, 2019·Nature Nanotechnology·Gregory V LowryLeanne M Gilbertson
May 14, 2021·Current Opinion in Plant Biology·Jeffrey W WangMarkita P Landry
May 15, 2021·Environmental Science & Technology·Astrid AvellanGregory V Lowry
Jun 12, 2021·Frontiers in Chemistry·Mukesh MeenaPriyankaraj Sonigra
Jun 15, 2021·Frontiers in Plant Science·Sunny AhmarKi-Hung Jung
Jul 21, 2021·Environmental Science & Technology·Yilin ZhangGregory V Lowry
Mar 5, 2020·Journal of Agricultural and Food Chemistry·Titir GuhaAmitava Mukherjee
Oct 27, 2021·Advanced Materials·Yong YanFeng Wang

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Methods Mentioned

BETA
confocal microscopy
dynamic light scattering
Scanning electron microscopy
Scanning Microscopy
cyclic dialysis
dynamic light-scattering
transmission electron microscopy

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