Therapeutic neovascularization promoted by injectable hydrogels

Bioactive Materials
Amrita PalMehdi Nikkhah

Abstract

The aim of therapeutic neovascularization is to repair ischemic tissues via formation of new blood vessels by delivery of angiogenic growth factors, stem cells or expansion of pre-existing cells. For efficient neovascularization, controlled release of growth factors is particularly necessary since bolus injection of molecules generally lead to a poor outcome due to inadequate retention within the injured site. In this regard, injectable hydrogels, made of natural, synthetic or hybrid biomaterials, have become a promising solution for efficient delivery of angiogenic factors or stem and progenitor cells for in situ tissue repair, regeneration and neovascularization. This review article will broadly discuss the state-of-the-art in the development of injectable hydrogels from natural and synthetic precursors, and their applications in ischemic tissue repair and wound healing. We will cover a wide range of in vitro and in vivo studies in testing the functionalities of the engineered injectable hydrogels in promoting tissue repair and neovascularization. We will also discuss some of the injectable hydrogels that exhibit self-healing properties by promoting neovascularization without the presence of angiogenic factors.

Citations

Aug 2, 2019·Current Cardiology Reports·Martin L TomovVahid Serpooshan
Sep 25, 2019·Pharmaceutics·Giuseppe CirilloFrancesca Iemma
Jul 30, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Alejandra Patino-GuerreroMehdi Nikkhah
Oct 23, 2019·Advanced Science·Xin ZhaoYuanjin Zhao
Oct 3, 2020·Bioactive Materials·Ting SuJianliang Shen
Mar 22, 2021·Preventive Veterinary Medicine·Blayra Maldonado-CabreraAna Sanches-Silva
Nov 2, 2020·International Journal of Biological Macromolecules·Annapoorna Mohandas, Jayakumar Rangasamy
Apr 21, 2021·Macromolecular Rapid Communications·Chunxiang MoYuping Chen
Jan 25, 2020·ACS Applied Materials & Interfaces·Olena IvashchenkoStefan Jurga
Aug 28, 2021·Journal of Functional Biomaterials·Daniela Medrano-DavidPedronel Araque-Marín
Aug 30, 2021·Acta Biomaterialia·Hamid EsmaeiliMehdi Nikkhah

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