Abstract
Glycemic control in elderly persons with type 2 diabetes mellitus (T2DM) is challenging because they are more likely to have other age-associated medical conditions and to experience hypoglycemia during intensive therapy. A best therapeutic strategy for these patients has not yet been defined. We investigated the efficacy and safety of adding once-daily insulin glargine to patients' current oral antidiabetic drugs (OAD) regimen, compared to increasing the OAD doses. The study enrolled patients aged 65 years or more, with poor glycemic control. Patients were randomized to two groups and entered a 3-week titration period in which their actual therapy was adjusted to meet the study's glycemic goals, by either adding insulin glargine to current therapy (group A, 27 patients) or increasing current OAD dosages (group B, 28 patients). Thereafter, therapies were continued unchanged for a 24-week observation period. The mean therapeutic dosage of insulin glargine in group A was 14.9 IU/day (SD = 5.0 IU/day). During the observation period, mean levels of glycosylated hemoglobin (HbA1c) reduced by 1.5% in group A and 0.6% in group B (P = 0.381). An HbA1c level <7.0% was achieved by five patients in each group. Mean fasting blood glucose l...Continue Reading
References
Jun 1, 1990·Diabetes Care·M C Riddle
May 1, 1989·Diabetes·M R TaskinenH Yki-Järvinen
Feb 1, 1995·Diabetes·M L ShankR A DeFronzo
Oct 1, 1995·Diabetes/metabolism Reviews·U Di MarioG Pozzessere
Apr 1, 1997·Diabetes Care·M Peyrot, R R Rubin
Feb 1, 1997·Diabetes Care·K MatykaS A Amiel
Aug 11, 1997·Archives of Internal Medicine·R I ShorrM R Griffin
May 8, 1998·Diabetes Care·M I HarrisD D Byrd-Holt
Jan 27, 2000·Archives of Internal Medicine·E W GreggS R Cummings
Mar 25, 2000·Journal of the American Geriatrics Society·R I ShorrM Pahor
Aug 11, 2000·Diabetes Care·H Yki-JärvinenUNKNOWN HOE 901/300s Study Group
Sep 12, 2000·Lancet·G B Bolli, D R Owens
Apr 24, 2001·Diabetes Care·J RosenstockM B Edwards
Apr 16, 2003·Journal of the American Geriatrics Society·Arlene F BrownUNKNOWN California Healthcare Foundation/American Geriatrics Society Panel on Improving Care for Elders with Diabetes
May 27, 2003·Diabetes Care·Andreas HamannUNKNOWN HOE901/4007 Study Group
Oct 2, 2003·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·A HolsteinE-H Egberts
Oct 28, 2003·Diabetes Care·Matthew C RiddleUNKNOWN Insulin Glargine 4002 Study Investigators
Jan 29, 2005·Diabetes Care·Hans U JankaHannele Yki-Järvinen
Mar 1, 2006·Diabetes Care·Julio RosenstockGeorge Dailey
Oct 27, 2006·Diabetes Care·Kingston H Tseng
Feb 17, 2007·Journal of the American Geriatrics Society·Hans U JankaKlaus Busch
Citations
Aug 13, 2011·Diabetes, Obesity & Metabolism·C V AscheS R Nair
Apr 12, 2013·Cardiovascular Diabetology·Diethelm TschöpePetra-Maria Schumm-Draeger
Apr 4, 2012·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Adrian N C LauCatherine H Y Yu
Nov 23, 2013·Drugs & Aging·S KorsatkoT R Pieber
Aug 7, 2009·Wiener klinische Wochenschrift·Bernhard LudvikUNKNOWN Expertengruppe der Osterreichischen Diabetesgesellschaft
May 7, 2011·Acta Diabetologica·Carles Zafon, Carmen Creus
Feb 3, 2016·Drugs & Aging·Anuj BhargavaDavid S Oyer
Nov 18, 2011·Expert Opinion on Pharmacotherapy·Edoardo MannucciAndrea Rossi
Aug 6, 2008·Expert Opinion on Drug Metabolism & Toxicology·M A ElrishiM J Davies
May 16, 2014·Canadian Journal of Diabetes·Graydon S MeneillyDaniel Tessier
Sep 6, 2011·Maturitas·Kyaw SoeGül Bahtiyar
Apr 5, 2011·The American Journal of Geriatric Pharmacotherapy·Lal K Tanwani
Nov 26, 2009·Diabetic Medicine : a Journal of the British Diabetic Association·B H R WolffenbuttelS Martin
Jan 14, 2012·Journal of the American Geriatrics Society·Pearl LeeJeffrey Halter
Aug 14, 2012·Journal of the American Geriatrics Society·Robert J LigthelmJean-François Yale
May 9, 2015·Journal of the American Geriatrics Society·Rituparna BhattacharyaUsha Sambamoorthi
Dec 8, 2014·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Supriya MathurBrian M Frier
Mar 17, 2009·Expert Opinion on Pharmacotherapy·Stanislav GoykhmanMarc Rendell
Apr 11, 2017·Current Medical Research and Opinion·Usha SambamoorthiAnders Boss
Dec 6, 2008·Current Opinion in Clinical Nutrition and Metabolic Care
Dec 25, 2008·Current Opinion in Lipidology
Mar 21, 2009·Current Opinion in Endocrinology, Diabetes, and Obesity