PMID: 32127666DOI: 10.1038/d41573-020-00016-0Mar 5, 2020Paper

Therapeutic options for the 2019 novel coronavirus (2019-nCoV)

Nature Reviews. Drug Discovery
Guangdi Li, Erik De Clercq

Abstract

No abstract listed.

Associated Clinical Trials

Assessment of Netosis During COVID-19, Under Treatment With Anakinra, an Interleukin-1 Receptor Antagonist

Oct 20, 2020

Use of cSVF Via IV Deployment for Residual Lung Damage After Symptomatic COVID-19 Infection

Mar 30, 2020

References

Coronaviruses - drug discovery and therapeutic options

Feb 13, 2016·Nature Reviews. Drug Discovery·Alimuddin ZumlaKwok-Yung Yuen

Approved Antiviral Drugs over the Past 50 Years

Jun 10, 2016·Clinical Microbiology Reviews·Erik De Clercq, Guangdi Li

New Nucleoside Analogues for the Treatment of Hemorrhagic Fever Virus Infections.

Aug 8, 2019·Chemistry, an Asian Journal·Erik De Clercq

First Case of 2019 Novel Coronavirus in the United States

Feb 1, 2020·The New England Journal of Medicine·Michelle L HolshueUNKNOWN Washington State 2019-nCoV Case Investigation Team

Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro.

Feb 6, 2020·Cell Research·Manli WangGengfu Xiao

Learning from the Past: Possible Urgent Prevention and Treatment Options for Severe Acute Respiratory Infections Caused by 2019-nCoV

Feb 6, 2020·Chembiochem : a European Journal of Chemical Biology·Jared S MorseWenshe Ray Liu

❮ Previous
Next ❯

Citations

Angiotensin receptor blockers as tentative SARS-CoV-2 therapeutics

Mar 5, 2020·Drug Development Research·David Gurwitz

A systematic review of lopinavir therapy for SARS coronavirus and MERS coronavirus-A possible reference for coronavirus disease-19 treatment option

Feb 28, 2020·Journal of Medical Virology·Tian-Tian YaoGui-Qiang Wang

COVID-19, an emerging coronavirus infection: advances and prospects in designing and developing vaccines, immunotherapeutics, and therapeutics.

Mar 19, 2020·Human Vaccines & Immunotherapeutics·Kuldeep DhamaWanpen Chaicumpa

Considering mutational meltdown as a potential SARS-CoV-2 treatment strategy.

Apr 7, 2020·Heredity·Jeffrey D Jensen, Michael Lynch

COVID-19 and the Heart

Apr 8, 2020·Circulation Research·Akbarshakh Akhmerov, Eduardo Marban

Controversial treatments: An updated understanding of the coronavirus disease 2019

Mar 29, 2020·Journal of Medical Virology·Cantong ZhangYong Dai

Pharmacologic Treatments for Coronavirus Disease 2019 (COVID-19): A Review.

Apr 14, 2020·JAMA : the Journal of the American Medical Association·James M SandersJames B Cutrell

Master Regulator Analysis of the SARS-CoV-2/Human Interactome

Apr 5, 2020·Journal of Clinical Medicine·Pietro H GuzziFederico M Giorgi

Favipiravir: Pharmacokinetics and Concerns About Clinical Trials for 2019-nCoV Infection

Apr 5, 2020·Clinical Pharmacology and Therapeutics·Yin-Xiao Du, Xiao-Ping Chen

A deadly spillover: SARS-CoV-2 outbreak

Apr 24, 2020·Expert Opinion on Therapeutic Patents·Mattia MoriClaudiu T Supuran

Harnessing innate immunity to eliminate SARS-CoV-2 and ameliorate COVID-19 disease.

Apr 11, 2020·Physiological Genomics·Rachel M GolonkaMatam Vijay-Kumar

Medical treatment options for COVID-19

May 5, 2020·European Heart Journal. Acute Cardiovascular Care·Leen Delang, Johan Neyts

A Trial of Lopinavir-Ritonavir in Covid-19

May 6, 2020·The New England Journal of Medicine·Daniel Havlichek

Review of Emerging Pharmacotherapy for the Treatment of Coronavirus Disease 2019

Apr 8, 2020·Pharmacotherapy·Ashley BarlowMojdeh S Heavner

Scientific research progress of COVID-19/SARS-CoV-2 in the first five months.

Apr 23, 2020·Journal of Cellular and Molecular Medicine·Hua LiJunbo Ge

Drug Development and Medicinal Chemistry Efforts Toward SARS-Coronavirus and Covid-19 Therapeutics

Apr 24, 2020·ChemMedChem·Arun K GhoshAndrew D Mesecar

Phytotherapic compounds against coronaviruses: Possible streams for future research

May 1, 2020·Phytotherapy Research : PTR·Michele AntonelliFabio Firenzuoli

A global treatments for coronaviruses including COVID-19

May 13, 2020·Journal of Cellular Physiology·Bahman YousefiMajid Eslami

Off-target ACE2 ligands: possible therapeutic option for CoVid-19?

May 3, 2020·British Journal of Clinical Pharmacology·Simone Brogi, Vincenzo Calderone

Risk of Increased Physical Inactivity During COVID-19 Outbreak in Older People: A Call for Actions

May 12, 2020·Journal of the American Geriatrics Society·Hamilton RoschelBruno Gualano

COVID-19: Important Therapy Considerations and Approaches in this Hour of Need

Apr 9, 2020·Pharmacotherapy·Thomas P Lodise, Michael J Rybak

The lysosome: A potential juncture between SARS-CoV-2 infectivity and Niemann-Pick disease type C, with therapeutic implications

May 6, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Rami A BalloutAlan T Remaley

Ideas for how informaticians can get involved with COVID-19 research

May 19, 2020·BioData Mining·Jason H MooreJohn H Holmes

COVID-19-associated cardiovascular morbidity in older adults: a position paper from the Italian Society of Cardiovascular Researches.

May 21, 2020·GeroScience·F MocciaT Angelone

Identification of bioactive molecules from tea plant as SARS-CoV-2 main protease inhibitors.

May 14, 2020·Journal of Biomolecular Structure & Dynamics·Vijay Kumar BhardwajSanjay Kumar

Development of remdesivir repositioning as a nucleotide analog against COVID-19 RNA dependent RNA polymerase.

May 14, 2020·Journal of Biomolecular Structure & Dynamics·Mohammad Mahdi Nejadi BabadaeiMojtaba Falahati

The hallmarks of COVID-19 disease

May 23, 2020·PLoS Pathogens·Daolin TangRui Kang

Knowledge-based structural models of SARS-CoV-2 proteins and their complexes with potential drugs

May 8, 2020·FEBS Letters·Atsushi HijikataTsuyoshi Shirai

COVID-19 and Cancer: a Comprehensive Review.

May 10, 2020·Current Oncology Reports·Rohit GosainMarc S Ernstoff

Rapid repurposing of drugs for COVID-19

May 10, 2020·Science·R Kiplin GuyRebecca E Dutch

Old and re-purposed drugs for the treatment of COVID-19.

May 19, 2020·Expert Review of Anti-infective Therapy·Shio-Shin Jean, Po-Ren Hsueh

In Silico Evaluation of the Effectivity of Approved Protease Inhibitors against the Main Protease of the Novel SARS-CoV-2 Virus

Jun 4, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Phaedra EleftheriouAthina Geronikaki

Direct oral anticoagulant plasma levels' striking increase in severe COVID-19 respiratory syndrome patients treated with antiviral agents: The Cremona experience.

Apr 25, 2020·Journal of Thrombosis and Haemostasis : JTH·Sophie TestaGualtiero Palareti

Simulated Assessment of Pharmacokinetically Guided Dosing for Investigational Treatments of Pediatric Patients With Coronavirus Disease 2019.

Jun 6, 2020·JAMA Pediatrics·Anil R MaharajUNKNOWN Best Pharmaceuticals for Children Act–Pediatric Trials Network Steering Committee

SARS, MERS and SARS-CoV-2 (COVID-19) treatment: a patent review

May 21, 2020·Expert Opinion on Therapeutic Patents·José Adão Carvalho Nascimento JuniorMairim Russo Serafini

An off-the-Shelf Approach for the Production of Fc Fusion Proteins by Protein Trans -Splicing towards Generating a Lectibody In Vitro

Jun 7, 2020·International Journal of Molecular Sciences·Anniina JaakkonenHideo Iwaï

Lung under attack by COVID-19-induced cytokine storm: pathogenic mechanisms and therapeutic implications

Jun 17, 2020·Therapeutic Advances in Respiratory Disease·Corrado PelaiaGirolamo Pelaia

Tackling SARS-CoV-2: proposed targets and repurposed drugs

Jun 23, 2020·Future Medicinal Chemistry·Siddhi JoshiMariam S Degani

SARS-coronavirus-2 replication in Vero E6 cells: replication kinetics, rapid adaptation and cytopathology

Jun 23, 2020·The Journal of General Virology·Natacha S OgandoEric J Snijder

Binding insight of clinically oriented drug famotidine with the identified potential target of SARS-CoV-2.

Jun 25, 2020·Journal of Biomolecular Structure & Dynamics·Parth Sarthi Sen GuptaMalay Kumar Rana

Autophagy as an emerging target for COVID-19: lessons from an old friend, chloroquine.

Jun 12, 2020·Autophagy·Srinivasa Reddy BonamDaniel J Klionsky

Estimation of reproduction numbers of COVID-19 in typical countries and epidemic trends under different prevention and control scenarios.

May 30, 2020·Frontiers of Medicine·Chen XuYong Cai

Diagnosis and management of the drug hypersensitivity reactions in Coronavirus disease 19

Jun 9, 2020·Allergy·Aslı GelincikMaria Jose Torres

COVID-19 and Lessons to Be Learned from Prior Coronavirus Outbreaks

Apr 9, 2020·Annals of the American Thoracic Society·Meagan E Deming, Wilbur H Chen

In silico analysis and identification of promising hits against 2019 novel coronavirus 3C-like main protease enzyme.

Jul 2, 2020·Journal of Biomolecular Structure & Dynamics·Shilpa ChatterjeeDebanjan Sen

COVID-19: Emergence, Spread, Possible Treatments, and Global Burden

Jun 24, 2020·Frontiers in Public Health·Raghuvir KeniKrishnadas Nandakumar

RNA-Dependent RNA Polymerase as a Target for COVID-19 Drug Discovery

Jul 15, 2020·SLAS Discovery·Wei ZhuWei Zheng

Current State of Research About Chinese Herbal Medicines (CHM) for the Treatment of Coronavirus Disease 2019 (COVID-19): A Scoping Review

Jun 27, 2020·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Jesús López-AlcaldeJürgen Barth

Computer-aided screening for potential TMPRSS2 inhibitors: a combination of pharmacophore modeling, molecular docking and molecular dynamics simulation approaches.

Jul 17, 2020·Journal of Biomolecular Structure & Dynamics·Mukhtar Oluwaseun IdrisOlanrewaju Ayodeji Durojaye

Designing a multi-epitope vaccine against SARS-CoV-2: an immunoinformatics approach.

Jul 18, 2020·Journal of Biomolecular Structure & Dynamics·Abdus SamadMd Shahedur Rahman

❮ Previous
Next ❯

Datasets Mentioned

BETA
MN908947.3

Clinical Trials Mentioned

NCT04252664
NCT04257656

Software Mentioned

PyMOL

Related Concepts

Related Feeds

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Anti-Arrhythmic Drug Therapies

Anti-arrhythmic drugs are used to prevent abnormal heart rhythms. These medications are used in conditions including, ventricular tachycardia, ventricular fibrillation and atrial fibrillation. Discover the latest research on anti-arrhythmic drug therapies here.

Related Papers

The 2019 Novel Coronavirus (2019-nCoV): Novel Virus, Old Challenges

(opens in new tab)
Acta Médica Portuguesa
Raquel DuarteCarlos Filipe Afonso Carvalho
ContactHelpTerms Privacy Cookies
© 2022 Meta ULC. All rights reserved