May 20, 2020

Therapeutic options for the management of severe Covid-19: A rheumatology perspective

Reumatología clinica
Claudia Mendoza-PintoSocorro Méndez-Martínez

Abstract

The novel SARS-CoV-2 human coronavirus in Wuhan, China, has triggered a worldwide respiratory disease outbreak (COVID-19). Acute respiratory distress syndrome (ARDS), multiorgan dysfunction and thrombotic events are among the leading causes of death in critically ill patients with COVID-19. The elevated inflammatory cytokines suggest that a "cytokine storm", also known as cytokine release syndrome (CRS), may play a major role in the pathology of COVID-19. In addition to anti-viral therapy and supportive treatment in critically ill patients, unique medications for this condition are also under investigation. Here we reviewed therapeutic options, including the antibody therapy that might be an immediate strategy for SARS-CoV-2 therapy.

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Mentioned in this Paper

Respiratory Distress Syndrome, Adult
Cytokine Release Syndrome
Cessation of Life
Pathology
TWIST1
A 19
Respiration Disorders
Antibody Therapy
Supportive Care
Cytokine

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