Therapeutic Options for Unscheduled Bleeding Associated with Long-Acting Reversible Contraception

Obstetrics and Gynecology Clinics of North America
EmmaKate Friedlander, Bliss Kaneshiro


Long-acting reversible contraception (LARC) is the most effective form of reversible contraception. Although most women are satisfied with LARC methods, unscheduled bleeding and spotting are common reasons for method dissatisfaction and discontinuation. This systematic analysis of the current literature delineates treatment options for unscheduled bleeding related to LARC use. Although consistent results are lacking, all devices seem to have the best response to nonsteroidal antiinflammatory drugs for 5 to 7 days or the antifibrinolytic agent tranexamic acid. Additional studies are necessary to identify improved treatment interventions for unscheduled bleeding with LARC use.


Jul 1, 1987·Contraception·M Toppozada
Mar 1, 1986·British Journal of Obstetrics and Gynaecology·L Mäkäräinen, O Ylikorkala
Feb 14, 2006·Contraception·Vorapong PhupongSurasak Taneepanichskul
Sep 29, 2007·Contraception·Caroline MoreauJames Trussell
Aug 9, 2008·The European Journal of Contraception & Reproductive Health Care : the Official Journal of the European Society of Contraception·Diana MansourIan S Fraser
Mar 13, 2010·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Suman LalNutan Agarwal
Apr 12, 2011·Contraception·Petra M CaseyJessica E Bury
Nov 8, 2011·American Journal of Obstetrics and Gynecology·Tessa MaddenJeffrey F Peipert


Sep 24, 2019·The European Journal of Contraception & Reproductive Health Care : the Official Journal of the European Society of Contraception·Andrea M PetersonAngela R Dempsey
Jul 22, 2020·Current Opinion in Pediatrics·Alexandra J EdwardsSarah Pitts

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Hereditary Sensory Autonomic Neuropathy

Hereditary Sensory Autonomic Neuropathies are a group of inherited neurodegenerative disorders characterized clinically by loss of sensation and autonomic dysfunction. Here is the latest research on these neuropathies.

Spatio-Temporal Regulation of DNA Repair

DNA repair is a complex process regulated by several different classes of enzymes, including ligases, endonucleases, and polymerases. This feed focuses on the spatial and temporal regulation that accompanies DNA damage signaling and repair enzymes and processes.

Glut1 Deficiency

Glut1 deficiency, an autosomal dominant, genetic metabolic disorder associated with a deficiency of GLUT1, the protein that transports glucose across the blood brain barrier, is characterized by mental and motor developmental delays and infantile seizures. Follow the latest research on Glut1 deficiency with this feed.

Separation Anxiety

Separation anxiety is a type of anxiety disorder that involves excessive distress and anxiety with separation. This may include separation from places or people to which they have a strong emotional connection with. It often affects children more than adults. Here is the latest research on separation anxiety.

KIF1A Associated Neurological Disorder

KIF1A associated neurological disorder (KAND) is a rare neurodegenerative condition caused by mutations in the KIF1A gene. KAND may present with a wide range and severity of symptoms including stiff or weak leg muscles, low muscle tone, a lack of muscle coordination and balance, and intellectual disability. Find the latest research on KAND here.

Regulation of Vocal-Motor Plasticity

Dopaminergic projections to the basal ganglia and nucleus accumbens shape the learning and plasticity of motivated behaviors across species including the regulation of vocal-motor plasticity and performance in songbirds. Discover the latest research on the regulation of vocal-motor plasticity here.

Related Papers

The British Journal of General Practice : the Journal of the Royal College of General Practitioners
Scott Wilkes
Journal of the Japanese Obstetrical & Gynecological Society
T Kobayashi, J Sugiura
© 2021 Meta ULC. All rights reserved