Therapeutic outcomes in non-small cell lung cancer with BRAF mutations: a single institution, retrospective cohort study

Translational Lung Cancer Research
Irena TanJeffrey M Clarke

Abstract

Data describing therapeutic outcomes in patients with non-small cell lung cancers (NSCLC) with BRAF mutations remains limited. We conducted a retrospective cohort study of 31 patients with metastatic NSCLC treated at Duke University Hospital who had been identified by next-generation sequencing methods to bear a BRAF mutation in their tumor in order to evaluate clinical response to immunotherapy and chemotherapy. Sixty-five percent of patients identified in this cohort were current or former smokers. Fourteen (45.2%) of patients had a BRAF V600E mutation and 17 (54.8%) had a non-V600E mutation. Median progression-free survival (PFS) in the 23 patients who received first-line chemotherapy was 6.4 months [95% confidence interval (CI), 2.3 to 13.0]. Overall survival (OS) in patients who received first-line chemotherapy showed a median survival of 18 months (95% CI, 7.4 to 28.6). OS comparing patients who had never received immunotherapy at any point was 18.4 months (95% CI, 4.1 to NE) compared to 19.0 months (95% CI, 9.9 to 28.6) in those who had received immunotherapy. We did not find a statistically significant difference in OS in patients with BRAF V600E, BRAF amplification, or non-V600E mutations. There was also no difference ...Continue Reading

Citations

Apr 17, 2020·Current Oncology Reports·Alessandro RussoChristian Rolfo
Jun 3, 2020·Critical Reviews in Oncology/hematology·Daniele FrisoneAlfredo Addeo
Apr 3, 2021·Cancer Treatment Reviews·Alfredo AddeoAlex Friedlaender
Oct 11, 2020·Critical Reviews in Oncology/hematology·Umberto MalapelleGiancarlo Troncone

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