PMID: 6540414Sep 1, 1984Paper

Therapeutic plasma levels of phenytoin, phenobarbital, and carbamazepine: individual variation in relation to seizure frequency and type

Neurology
D Schmidt, F Haenel

Abstract

The range and clinical features that influence the individual variation of the therapeutic plasma concentration of phenytoin, phenobarbital, and carbamazepine were studied in 84 epileptic patients on single-drug therapy. Complete cessation of seizures was observed at plasma concentrations of 17.9 (3 to 50) micrograms/ml phenytoin, 24.5 (3 to 43) micrograms/ml phenobarbital, and 6.5 (4.8 to 9.7) micrograms/ml carbamazepine. Fifty-one percent of the 53 patients receiving phenytoin were completely controlled at either below or above the 10 to 20 micrograms/ml range, suggesting that individual dosage adjustment is preferably based on clinical judgment rather than numerical limits of published therapeutic ranges. Fifty patients with therapeutic plasma concentrations of or above 15 micrograms/ml phenytoin, 25 micrograms/ml plasma concentrations of or above 15 micrograms/ml phenytoin, 25 micrograms/ml phenobarbital, or 6 micrograms/ml carbamazepine more often had partial epilepsies, complex partial seizures and, most markedly, a higher number of seizures in the first year of epilepsy and during the year prior to the present drug therapy, when compared with 34 patients with lower therapeutic plasma concentrations. The variation in ther...Continue Reading

Citations

May 1, 1990·Neurotoxicology and Teratology·J AdamsL D Middaugh
Nov 26, 2002·Epilepsy Research·Dieter SchmidtGregory L Holmes
Nov 26, 2002·Epilepsy Research·Emilio Perucca
May 1, 1985·Epilepsia·R H Levy, D Schmidt
May 8, 2009·Epilepsy Currents·Dieter Schmidt, Wolfgang Löscher
Apr 5, 2000·Clinical Pharmacokinetics·E Perucca
Apr 29, 1998·Therapeutic Drug Monitoring·A SundqvistB Lundkvist
Feb 15, 2013·Therapeutic Drug Monitoring·Santosh R TaurUrmila M Thatte
Mar 1, 1987·Current Problems in Pediatrics·R R Clancy
Apr 25, 2000·Seizure : the Journal of the British Epilepsy Association·J P Leach
Jul 19, 2016·Clinical Neuropharmacology·Rachel G GreenbergJeffrey T Guptill
Dec 7, 2000·Journal of Child Neurology·S R Snodgrass, B R Parks
Jul 28, 2018·Journal of Clinical Pharmacology·Min-Jee KimHyeong-Seok Lim
Feb 15, 2020·Expert Opinion on Drug Metabolism & Toxicology·Cecilie Johannessen LandmarkPhilip N Patsalos
Aug 1, 1988·Developmental Medicine and Child Neurology·J Aicardi
Aug 1, 1986·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·K FarrellP K Wong
Nov 1, 1993·The Annals of Pharmacotherapy·G Hayes, M E Kootsikas
Nov 5, 2005·CNS Drugs·Emilio Perucca, Patrick Kwan
Jan 1, 1994·Acta Neurologica Scandinavica·U SpechtP Wolf
May 4, 1999·Pediatric Annals·S R Snodgrass
Feb 1, 1997·Epilepsia·B E Gidal, T E Welty
Jul 22, 2017·Frontiers in Neurology·Fei TangBjörn Bauer

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