PMID: 6975635Sep 1, 1981Paper

Therapeutic plasmapheresis in systemic lupus erythematosus. Effect on immune complexes and antibodies to DNA

Arthritis and Rheumatism
J V JonesB C McLeod

Abstract

The effect of plasmapheresis in 8 patients with systemic lupus erythematosus (SLE) was investigated. Drug treatment was maintained at a constant level for at least 4 weeks before plasmapheresis. Levels of immune complexes were measured by a Raji cell radioimmunoassay, and by a solid-phase C1q-binding assay. Antibodies to ds-DNA and ss-DNA were measured by the Farr assay. In all cases, immune complexes and antibodies were lowered by plasmapheresis. In 5 patients, plasmapheresis was followed by a rapid rebound of complexes and antibody to pretreatment levels. In 3 in whom plasmapheresis was followed by treatment with cyclophosphamide for 1 month, a sustained immunochemical and clinical improvement followed, lasting in 2 cases for up to 3 years.

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Citations

Oct 16, 2002·Journal of Clinical Apheresis·Bruce C McLeod
Jul 1, 1987·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·S C JordanR N Fine
Jul 1, 1989·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·J S Cameron
Sep 29, 2005·Rheumatology International·Helmut SoerensenWolfgang Ramlow
Mar 18, 1999·Therapeutic Apheresis : Official Journal of the International Society for Apheresis and the Japanese Society for Apheresis·A A Kaplan
May 17, 2001·Therapeutic Apheresis : Official Journal of the International Society for Apheresis and the Japanese Society for Apheresis·A A Kaplan
May 2, 2002·Therapeutic Apheresis : Official Journal of the International Society for Apheresis and the Japanese Society for Apheresis·Y MoriyaH Tsuda
Sep 29, 2005·Hematology·Bruce C McLeod
Aug 1, 1997·Therapeutic Apheresis : Official Journal of the International Society for Apheresis and the Japanese Society for Apheresis·A A Kaplan
Mar 1, 1993·Annals of the Rheumatic Diseases·F H Van den HoogenA J Croockewit
Sep 29, 1984·British Medical Journal·T Hamblin
Jan 1, 1993·Journal of Clinical Apheresis·D O KasprisinB C McLeod
Sep 1, 1989·Journal of the American Academy of Dermatology·F CornelisS Sigal
Mar 21, 2007·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Christian Pagnoux
Feb 20, 2013·Journal of Clinical Apheresis·Andre A Kaplan
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Jul 1, 1985·Clinics in Dermatology·D L Tuffanelli
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Oct 14, 2017·Rheumatology·Caroline GordonUNKNOWN British Society for Rheumatology Standards, Audit and Guidelines Working Group
Aug 16, 2003·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Andre A Kaplan
Jan 1, 1982·Journal of Clinical Apheresis·D J WallaceJ R Klinenberg

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