PMID: 11328775May 1, 2001Paper

Therapeutic possibilities of long-term roxithromycin treatment for chronic diffuse sclerosing osteomyelitis of the mandible

The Journal of Antimicrobial Chemotherapy
T YoshiiT Komori

Abstract

The clinical efficacy of long-term roxithromycin treatment was examined objectively in nine patients with chronic diffuse sclerosing osteomyelitis of the mandible. Roxithromycin was administered orally at a dose of 300 mg/day for between 68 days and 66 months. In seven of the nine cases (77.8%), the symptoms disappeared 1-12 months after the start of therapy. Radiography showed that osteolytic changes (evident from 'moth-eaten' appearance of bone) had improved but that osteosclerosis had persisted or become more predominant by the end of therapy. Therefore, the optimum duration of treatment should be decided according to the amelioration of symptoms along with the disappearance of osteolytic findings in radiographs. Diarrhoea and stomach discomfort occurred in one case, and liver dysfunction in another, but these adverse reactions were relatively mild. The mechanism of action of roxithromycin in this study is not yet fully understood, but our results indicate that long-term roxithromycin treatment may be useful for diffuse sclerosing osteomyelitis of the mandible and should be attempted before surgical treatment is considered.

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Citations

Apr 10, 2010·Annals of Nuclear Medicine·Nobuyoshi FukumitsuGen-yuki Yamane
May 21, 2011·Dental Materials Journal·Gaku TamazawaTazuko Satoh
Dec 3, 2014·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·Antonio MaríJesus Rodríguez
Oct 1, 2015·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·Sven OttoWenko Smolka
Dec 20, 2007·Oral and Maxillofacial Surgery Clinics of North America·Marjut Montonen, Christian Lindqvist
Feb 12, 2011·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Nadja KadomGilbert Vezina
Jul 24, 2012·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Runzhi DengJing Hao
Dec 10, 2009·The Open Orthopaedics Journal·Ch MatzaroglouM Karanikolas
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