Therapeutic potential effect of bone marrow-derived mesenchymal stem cells on chronic liver disease in murine Schistosomiasis Mansoni

Journal of Parasitic Diseases : Official Organ of the Indian Society for Parasitology
Mohamed H HegabMohammed Abu El-Magd

Abstract

Some reports have shown that mesenchymal stem cells (MSCs) therapy could ameliorate chemically-induced hepatic fibrosis. This research assesses the therapeutic action of bone marrow mesenchymal stem cells (BM-MSCs) on chronic diseased liver in Schistosoma mansoni infected mice. All infected female mice divided into three groups, one group (15 mice) treated with oral praziquantel (PZQ), second group (15 mice) received intravenous injection of BM-MSCs and third group (15 mice) treated with both MSCs + PZQ. Two control groups (15 mice each) subdivided into one infected and second healthy one. BM-MSCs were obtained from bones of both femur and tibia of male mice (30 mice), then cultured and characterized morphologically by detection of CD105 by flow cytometer. Liver tissues for all groups were examined histopathologically. Measuring of the collagen 1 gene expression was done by real-time PCR and immunohistochemical study to detect stem cells differentiation for detection of MSCs engraftments in liver tissue. MSCs treatment caused marked improvement and regression of fibrosis, and prevents deposition of collagen and reduced the expression of collagen 1 gene in infected mice on their liver tissues, especially when used with PZQ in mi...Continue Reading

References

May 15, 1999·Science·B E PetersenJ P Goff
Dec 20, 2002·Mechanisms of Development·Nelson Fausto, Jean S Campbell
Dec 21, 2002·Journal of Cellular Physiology·Luana CalabròMichele Maio
Jul 17, 2003·The Journal of Clinical Investigation·Orit KolletTsvee Lapidot
Aug 7, 2003·Proceedings of the National Academy of Sciences of the United States of America·Xin WangMarkus Grompe
Aug 16, 2003·Proceedings of the National Academy of Sciences of the United States of America·Yoshiyuki Kanazawa, Inder M Verma
Oct 4, 2003·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Marc H Dahlke, Hans J Schlitt
Sep 14, 2004·Immunological Reviews·Thomas A WynnMargaret M Mentink-Kane
Oct 6, 2004·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·C Di CampliA Gasbarrini
Nov 27, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Isao SakaidaKiwamu Okita
Jun 11, 2005·World Journal of Gastroenterology : WJG·Dong-Chang ZhaoPeng Xiang
Feb 21, 2006·World Journal of Gastroenterology : WJG·Colette C ProsserJian Wu
Jun 30, 2006·International Journal for Parasitology·Paul B BartleyDonald P McManus
Oct 16, 2008·World Journal of Gastroenterology : WJG·Sheilla Andrade OliveiraMilena-Botelho-Pereira Soares
Dec 9, 2008·Current Opinion in Organ Transplantation·Dhivya HaridassMichael Ott
Jan 13, 2009·International Journal of Experimental Pathology·Kei MoriyaHiroshi Fukui
Feb 24, 2009·Canadian Journal of Physiology and Pharmacology·Zeynep Tokcaer-KeskinKamil C Akcali
Oct 15, 2009·Parasite Immunology·Z A Andrade
Apr 21, 2010·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Nagwa ElkhafifGihan El Fandy
Oct 15, 2010·Differentiation; Research in Biological Diversity·Sadia MohsinSheikh Riazuddin
Jun 9, 2012·Experimental Biology and Medicine·Huijuan XuWenrong Xu
Jul 25, 2012·Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association·Gibran Ali, Muhammad S Masoud
Jun 6, 2013·Acta Pharmacologica Sinica·Xin WeiYu-fang Shi

❮ Previous
Next ❯

Citations

Aug 15, 2020·International Journal of Urology : Official Journal of the Japanese Urological Association·Rasha ZahranMohammed Abu El-Magd
Apr 25, 2019·Scientific Reports·Veruska Cintia Alexandrino de SouzaSheilla Andrade de Oliveira
Aug 21, 2020·Acta Parasitologica·Muslimah Alsulami, Rewaida Abdel-Gaber
Mar 30, 2019·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Mohammed A El-MagdMohamed A Basyony
Oct 7, 2021·Clinical Microbiology Reviews·Timothy D ShawCecilia M O'Kane

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.

© 2022 Meta ULC. All rights reserved