Therapeutic potential of A2 adenosine receptor pharmacological regulators in the treatment of cardiovascular diseases, recent progress, and prospective

Journal of Cellular Physiology
Amirhossein BahreyniSeyed Mahdi Hassanian

Abstract

Adenosine and its analogs are of particular interest as potential therapeutic agents for treatment of cardiovascular diseases (CVDs). A2 adenosine receptor subtypes (A2a and A2b) are extensively expressed in cardiovascular system, and modulation of these receptors using A2 adenosine receptor agonists or antagonists regulates heart rate, blood pressure, heart rate variability, and cardiovascular toxicity during both normoxia and hypoxia conditions. Regulation of A2 adenosine receptor signaling via specific and novel pharmacological regulators is a potentially novel therapeutic approach for a better understanding and hence a better management of CVDs. This review summarizes the role of pharmacological A2 adenosine receptor regulators in the pathogenesis of CVDs.

References

Feb 12, 1998·The American Journal of Physiology·B J Koos, A Chau
Dec 21, 2000·American Journal of Physiology. Heart and Circulatory Physiology·B J Koos, T Maeda
Mar 31, 2007·Cell Death and Differentiation·B B Fredholm
Sep 2, 2008·Nature Reviews. Drug Discovery·György HaskóPál Pacher
Sep 16, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Aaron J CarmanMargaret S Bynoe
Oct 25, 2011·Expert Opinion on Investigational Drugs·Stefania GessiPier Andrea Borea
Aug 4, 2012·Journal of the American College of Cardiology·David S CelermajerKam S Woo
Nov 6, 2012·Journal of Biomedicine & Biotechnology·Bertrand AllardJohn Stagg
Nov 13, 2014·Pharmacological Reviews·Pier Andrea BoreaStefania Gessi
Nov 20, 2015·Oxidative Medicine and Cellular Longevity·Yang BaiYang Zheng
Aug 26, 2016·Purinergic Signalling·Martha de Oliveira BravoFelipe Saldanha-Araujo
Jan 16, 2017·Molecular Aspects of Medicine·Maria PeleliMattias Carlström
Mar 25, 2017·Brain Sciences·Nathan T FriedMichael L Oshinsky
Apr 7, 2017·Journal of Cellular Physiology·Amirhossein BahreyniSeyed Mahdi Hassanian
May 23, 2017·Frontiers in Pharmacology·Elizabeth A VecchioLauren T May
Jun 8, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Werner J GeldenhuysMohammed A Nayeem
Jun 16, 2017·Journal of Cellular Physiology·Amirhossein BahreyniSeyed M Hassanian
Jul 1, 2017·Journal of Cellular Physiology·Amirhossein BahreyniSeyed M Hassanian
Aug 2, 2017·Neural Regeneration Research·Kunihiko Yamashiro, Mitsuhiro Morita

❮ Previous
Next ❯

Citations

Dec 1, 2019·International Journal of Molecular Sciences·Emmanuel FenouilletJean Ruf
Jun 18, 2020·International Journal of Nanomedicine·Rajasekharreddy PalaSurya M Nauli
Aug 29, 2021·Pharmaceuticals·Magdalena KotańskaKatarzyna Kieć-Kononowicz

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Homeostasis

Cardiovascular regulation and homeostasis is important in maintaining health and dysfunction may lead to cardiovascular diseases. Nitric oxide and vascular endothelium are one of many molecules involved in the homeostatic mechanism. Here is the latest research on cardiovascular homeostasis.

Related Papers

Expert Opinion on Therapeutic Patents
Stephanie Federico, Giampiero Spalluto
Pharmacological Reviews
I Feoktistov, I Biaggioni
Neurologia i neurochirurgia polska
Jadwiga Zalewska-Kaszubska
© 2022 Meta ULC. All rights reserved