Therapeutic potential of adult bone marrow-derived mesenchymal stem cells in prostate cancer bone metastasis.

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
D ChandaS Ponnazhagan

Abstract

Current evidence indicates that an osteoblast lesion in prostate cancer is preceded by osteolysis. Thus, prevention of osteolysis would reduce complications of bone metastasis. Bone marrow-derived mesenchymal stem cells have the ability to differentiate into osteoblast and produce osteoprotegerin, a decoy receptor for the receptor activator for nuclear factor kappaB ligand, naturally. The present study examined the potential of unmodified mesenchymal stem cells to prevent osteolytic bone lesions in a preclinical mouse model of prostate cancer. The human prostate cancer cell line PC3 was implanted in tibiae of severe combined immunodeficient mice. After establishment of the tumor, either unmodified or genetically engineered mesenchymal stem cells overexpressing osteoprotegerin was injected at the site of tumor growth. The effects of therapy were monitored by bioluminescence imaging, micro-computed tomography, immunohistochemistry, and histomorphometry. Data indicated significant (P < 0.001) inhibition of tumor growth and restoration of bone in mice treated with unmodified and modified mesenchymal stem cells. Detailed analysis suggested that the donor mesenchymal stem cell inhibited tumor progression by producing woven bone aroun...Continue Reading

References

Jan 28, 2003·Cancer·Theresa A GuiseKhalid S Mohammad
Jan 14, 2004·The Journal of Pharmacology and Experimental Therapeutics·Jude E OnyiaT John Martin
Apr 20, 2004·Experimental Cell Research·Philippe TropelFrançois Berger
Sep 10, 2004·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Rachel NyamboColby L Eaton
Sep 15, 2004·Biochimica Et Biophysica Acta·Y WittrantF Rédini
Nov 4, 2004·Journal of the National Cancer Institute·Matus StudenyMichael Andreeff
Jul 12, 2005·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Peter G WhangJay R Lieberman
Jan 13, 2006·Nature Clinical Practice. Oncology·Julie M BlairColin R Dunstan
Feb 9, 2006·Clinical Science·Ingunn Holen, Claire M Shipman
Oct 26, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Theresa A GuiseJohn M Chirgwin
Dec 13, 2006·Cancer Metastasis Reviews·Michel B ChoueiriSue-Hwa Lin
Dec 21, 2006·Cancer Metastasis Reviews·William C Dougall, Michelle Chaisson
Jan 24, 2007·CA: a Cancer Journal for Clinicians·Ahmedin JemalMichael J Thun
Jul 12, 2007·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Sanjay Kumar, Selvarangan Ponnazhagan
Oct 17, 2007·Molecular Cancer Therapeutics·Lauren A KingsleyTheresa A Guise
Mar 22, 2008·Gene Therapy·S KumarS Ponnazhagan
Apr 5, 2008·Molecular Therapy : the Journal of the American Society of Gene Therapy·Diptiman ChandaSelvarangan Ponnazhagan
Jul 22, 2008·The Journal of Urology·Martine P RoudierSusan M Ott
Aug 7, 2008·Nature Clinical Practice. Urology·Zohar A Dotan
Jan 22, 2013·CA: a Cancer Journal for Clinicians·Rebecca SiegelAhmedin Jemal

❮ Previous
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Citations

Feb 9, 2012·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Christopher T WinkelmannTimothy J Hoffman
Aug 24, 2010·Tissue Engineering. Part B, Reviews·Vera S DonnenbergAlbert D Donnenberg
Aug 27, 2013·Endocrine-related Cancer·W Nathaniel BrennenJohn T Isaacs
Jan 11, 2014·Seminars in Cancer Biology·Olivier De WeverMarc Bracke
Jun 28, 2014·BioMed Research International·Nadia Rucci, Adriano Angelucci
Jan 15, 2014·Cancer Metastasis Reviews·Leah M CookConor C Lynch
Mar 4, 2011·Journal of Proteome Research·Wenhong ZhuJeffrey W Smith
May 28, 2010·Journal of Cellular Biochemistry·Diptiman ChandaSelvarangan Ponnazhagan
Jun 12, 2013·Biochimie·Ludovic ZimmerlinAlbert D Donnenberg
Feb 20, 2015·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Anna LaurenzanaGabriella Fibbi
Jul 28, 2016·Stem Cells and Development·Adam NowakowskiBarbara Lukomska
Jan 30, 2013·Laboratory Investigation; a Journal of Technical Methods and Pathology·James J CodyJoanne T Douglas
Dec 14, 2018·Journal of Oral Science·Takaharu AbeKotaro Tanimoto
Jul 29, 2010·British Journal of Cancer·S BomkenJ Vormoor
May 17, 2018·Oncotarget·Camila Ramalho BonturiMaria Luiza Vilela Oliva
Sep 29, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Anandi SawantSelvarangan Ponnazhagan
Apr 5, 2018·Frontiers in Pharmacology·Daria S ChulpanovaValeriya V Solovyeva
Feb 12, 2020·European Journal of Pharmacology·Agata HadryśJoanna Jazowiecka-Rakus

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