Therapeutic potential of agmatine for CNS disorders

Neurochemistry International
Vivian B NeisAna Lucia S Rodrigues

Abstract

Agmatine is a neuromodulator that regulates multiple neurotransmitters and signaling pathways. Several studies have focused on elucidating the mechanisms underlying the neuroprotective effects of this molecule, which seems to be mediated by a reduction in oxidative damage, neuroinflammation, and proapoptotic signaling. Since these events are implicated in acute and chronic excitotoxicity-related disorders (ischemia, epilepsy, traumatic brain injury, spinal cord injury, neurodegenerative, and psychiatric disorders) as well as in nociception, agmatine has been proposed as a therapeutic strategy for the treatment of central nervous system (CNS) disorders. Agmatine also stimulates the expression of trophic factors and adult neurogenesis, contributing to its ability to induce endogenous repair mechanisms. Therefore, considering its wide range of biological effects, this review summarizes the current knowledge about its protective and regenerative properties in the CNS.

References

May 7, 2010·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·Y IizukaG J Seong
Jul 5, 2015·Neurochemical Research·Milica NinkovicPredrag Peric

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Citations

Feb 16, 2019·Expert Opinion on Therapeutic Targets·Devon WattsFlavio Kapczinski
Jul 3, 2018·Cardiovascular & Hematological Disorders Drug Targets·Luis Cobos-Puc, Hilda Aguayo-Morales
May 25, 2020·Naunyn-Schmiedeberg's Archives of Pharmacology·Vivian Binder NeisAna Lúcia S Rodrigues
Dec 13, 2019·Pharmacological Reviews·Henry SzechtmanKurt Leroy Hoffman
May 14, 2020·Neurotoxicity Research·Gislaine OlescowiczAna Lúcia S Rodrigues
May 23, 2020·Chronic Stress·Anderson Camargo, Ana Lúcia S Rodrigues
Nov 22, 2020·European Journal of Pharmacology·Sandip RahangdaleBrijesh Taksande
Apr 11, 2021·Neuroscience Letters·Özlem AkmanAyşe Karson
Jun 11, 2019·Toxicon : Official Journal of the International Society on Toxinology·Samyr Machado QuerobinoCarlos Alberto-Silva

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