PMID: 8955848Dec 1, 1996Paper

Therapeutic potential of anti-HIV immunotoxins

Antiviral Research
S H Pincus

Abstract

In vitro analyses have shown anti-HIV immunotoxins to be among the most effective AIDS antivirals tested. Because HIV has been continually selected by antibody, immunotoxins targeted to constant domains of viral antigens may not elicit drug-resistant mutants. A clinical trial with CD4-PE40, a possibly flawed immunotoxin with nonspecific toxicity and short serum half-life, has reduced interest in this form of therapy. It is proposed that the use of an immunotoxin directed against gp41 in combination with a CD4-Ig chimera is more likely to have a therapeutic effect than CD4-PE40. Clinical trials are also underway utilizing an immunotoxin that eliminates activated T-cells, an important cellular locus of HIV-replication.

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Citations

Jun 22, 2001·Critical Reviews in Oncology/hematology·D L NewtonS M Rybak
Mar 17, 2004·AIDS Research and Human Retroviruses·Kira K LuedersDean H Hamer
Jan 15, 2014·PLoS Pathogens·Paul W DentonJ Victor Garcia
Sep 30, 1998·Proceedings of the National Academy of Sciences of the United States of America·E A BergerI Pastan
Sep 29, 2015·The Journal of Clinical Investigation·Julia A M SungGuido Ferrari
Nov 30, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Andrea BolognesiLetizia Polito
Nov 18, 2014·Nature Reviews. Microbiology·Nancie M ArchinDavid M Margolis
Jul 18, 2002·The Journal of Biological Chemistry·Louise McHughDean H Hamer
Feb 8, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Seth H PincusWilliam C Olson
Feb 5, 2002·The Journal of Biological Chemistry·Andrea BolognesiFiorenzo Stirpe

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