Therapeutic Potential of Autophagy Modulation in Cholangiocarcinoma.

Cells
Hector Perez-Montoyo

Abstract

Autophagy is a multistep catabolic process through which misfolded, aggregated or mutated proteins and damaged organelles are internalized in membrane vesicles called autophagosomes and ultimately fused to lysosomes for degradation of sequestered components. The multistep nature of the process offers multiple regulation points prone to be deregulated and cause different human diseases but also offers multiple targetable points for designing therapeutic strategies. Cancer cells have evolved to use autophagy as an adaptive mechanism to survive under extremely stressful conditions within the tumor microenvironment, but also to increase invasiveness and resistance to anticancer drugs such as chemotherapy. This review collects clinical evidence of autophagy deregulation during cholangiocarcinogenesis together with preclinical reports evaluating compounds that modulate autophagy to induce cholangiocarcinoma (CCA) cell death. Altogether, experimental data suggest an impairment of autophagy during initial steps of CCA development and increased expression of autophagy markers on established tumors and in invasive phenotypes. Preclinical efficacy of autophagy modulators promoting CCA cell death, reducing invasiveness capacity and resensi...Continue Reading

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Citations

Aug 14, 2020·International Journal of Molecular Sciences·Rittibet YapasertRatana Banjerdpongchai
Dec 22, 2020·Frontiers in Cell and Developmental Biology·Jing-Li XuJiang-Jiang Qin
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Jul 2, 2021·Journal of Traditional and Complementary Medicine·Kesara Na-BangchangJuntra Karbwang

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Datasets Mentioned

BETA
ABTL0812

Methods Mentioned

BETA
surgical resection
xenografts
xenograft
lipidation
transgenic

Clinical Trials Mentioned

NCT02496741
NCT03377179
NCT01525719
NCT00973713
NCT02836847
NCT03768375
NCT00238212
NCT00919061
NCT00955721
NCT01093222

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An autophagosome is the formation of double-membrane vesicles that involve numerous proteins and cytoplasmic components. These double-membrane vesicles are then terminated at the lysosome where they are degraded. Discover the latest research on autophagosomes here.

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