Therapeutic potential of berberine against neurodegenerative diseases

Science China. Life Sciences
WenXiao JiangXiaoJiang Li

Abstract

Berberine (BBR) is an organic small molecule isolated from various plants that have been used in traditional Chinese medicine. Isolation of this compound was its induction into modern medicine, and its usefulness became quickly apparent as seen in its ability to combat bacterial diarrhea, type 2 diabetes, hypercholesterolemia, inflammation, heart diseases, and more. However, BBR's effects on neurodegenerative diseases remained relatively unexplored until its ability to stunt Alzheimer's disease (AD) progression was characterized. In this review, we will delve into the multi-faceted defensive capabilities and bio-molecular pathways of BBR against AD, Parkinson's disease (PD), and trauma-induced neurodegeneration. The multiple effects of BBR, some of which enhance neuro-protective factors/pathways and others counteract targets that induce neurodegeneration, suggest that there are many more branches to the diverse capabilities of BBR that have yet to be uncovered. The promising results seen provide a convincing and substantial basis to support further scientific exploration and development of the therapeutic potential of BBR against neurodegenerative diseases.

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Citations

Oct 18, 2015·Experimental Eye Research·Delu SongJoshua L Dunaief
Nov 7, 2017·Nucleic Acids Research·Lin HuangChengping Wen
Aug 21, 2019·Central Nervous System Agents in Medicinal Chemistry·Anurag K SinghGiriraj T Kulkarni
Mar 20, 2019·Expert Review of Neurotherapeutics·Rohit SharmaP K Prajapati
Sep 26, 2019·Frontiers in Cellular Neuroscience·Jia-Wen ShouPang-Chui Shaw
Apr 23, 2020·Frontiers in Bioengineering and Biotechnology·Seyed Zachariah MoradiMohammad Abdollahi
Feb 10, 2021·Critical Reviews in Food Science and Nutrition·Yi WangWing-Fu Lai
Mar 3, 2021·European Journal of Pharmacology·Tayebeh NooriSamira Shirooie
Apr 14, 2021·Bioorganic & Medicinal Chemistry·Sobhi GabaVikramdeep Monga
Apr 22, 2021·Degenerative Neurological and Neuromuscular Disease·Nafaa AlzobaidiMaaz Naqvi
Apr 27, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Apoorva M KulkarniKeun Woo Lee
Mar 9, 2021·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Song LiWeidong Le

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Methods Mentioned

BETA
transgenic

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