Therapeutic potential of CD8+ cytotoxic T lymphocytes in SLE.

Autoimmunity Reviews
I PuliaevaC S Via

Abstract

Recent evidence supports the idea that following a break in tolerance, CD8 cytotoxic T lymphocytes (CTL) may be an important but unrecognized mechanism for limiting expansion of autoreactive B cells. Failure of this mechanism could allow persistence of CD4 T cell driven polyclonal B cell activation resulting in clinical lupus. Although CD8 CTL failure may occur early in disease, work in mice supports the concept that therapeutic CTL enhancement may be both practical and beneficial in lupus. Devising such therapy for humans will first require an understanding of the in vivo mechanisms critical in CTL expansion and down regulation, particularly in the lupus setting which may differ from CTL generation in other clinical settings (e.g. tumors, infections).

References

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Dec 13, 2005·Autoimmunity Reviews·Akaluck Thatayatikom, Andrew J White

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Citations

Jan 30, 2014·International Reviews of Immunology·Tiffany CazaAndras Perl
Jun 19, 2012·Journal of Autoimmunity·Robert A Eisenberg, Charles S Via
Dec 20, 2011·Trends in Molecular Medicine·Alexandros P Grammatikos, George C Tsokos
Dec 14, 2011·Autoimmunity Reviews·Ram P SinghBevra H Hahn
Dec 21, 2010·Autoimmunity Reviews·Diana Gómez-MartínJorge Alcocer-Varela
Aug 19, 2010·Autoimmunity Reviews·Carlo Selmi
Apr 7, 2010·Trends in Immunology·Charles S Via
Feb 9, 2010·Trends in Molecular Medicine·José C CrispínGeorge C Tsokos
Aug 1, 2009·Autoimmunity Reviews·Emese KissPeter Szodoray
Sep 18, 2009·Annals of the New York Academy of Sciences·Carlo Selmi
Sep 17, 2013·Acta Oto-laryngologica·Shih-Lun ChangYung-Song Lin
Feb 8, 2014·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Nicole L RegnaChristopher M Reilly
Oct 14, 2016·Current Rheumatology Reports·Masayuki Mizui, George C Tsokos
May 3, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Anthony D FosterCharles S Via
Jul 27, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Masayuki MizuiGeorge C Tsokos
Mar 26, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kateryna SoloviovaCharles S Via
Jun 26, 2018·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Kateryna SoloviovaCharles S Via

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