Therapeutic potential of controlled drug delivery systems in neurodegenerative diseases

International Journal of Pharmaceutics
N Popovic, Patrik Brundin

Abstract

Several compounds that exhibit a therapeutic effect in experimental models of neurodegenerative diseases have been identified over recent years. Safe and effective drug delivery to the central nervous system is still one of the main obstacles in translating these experimental strategies into clinical therapies. Different approaches have been developed to enable drug delivery in close proximity to the desired site of action. In this review, we describe biodegradable polymeric systems as drug carriers in models of neurodegenerative diseases. Biomaterials described for intracerebral drug delivery are well tolerated by the host tissue and do not exhibit cytotoxic, immunologic, carcinogenic or teratogenic effects even after chronic exposure. Behavioral improvement and normalization of brain morphology have been observed following treatment using such biomaterials in animal models of Parkinson's, Alzheimer's and Huntington's diseases. Application of these devices for neuroactive drugs is still restricted due to the relatively small volume of tissue exposed to active compound. Further development of polymeric drug delivery systems will require that larger volumes of brain tissue are targeted, with a controlled and sustained drug relea...Continue Reading

References

Jul 1, 1989·Journal of Neurosurgery·M A HowardM R Mayberg
Feb 1, 1989·Journal of Biomedical Materials Research·R J TamargoH Brem
Jan 1, 1989·Selective Cancer Therapeutics·H BremK W Leong
Dec 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·L R WilliamsF H Gage
Jan 1, 1986·Journal of Biomedical Materials Research·K W LeongR Langer
Apr 1, 1983·Biomaterials·H B RosenR Langer
Jan 1, 1996·Journal of Biomaterials Science. Polymer Edition·C E KrewsonW M Saltzman
Aug 5, 1998·Biomaterials·S M IbimC T Laurencin
Apr 14, 1999·Proceedings of the National Academy of Sciences of the United States of America·M J Mahoney, W M Saltzman
Mar 4, 2000·Journal of Controlled Release : Official Journal of the Controlled Release Society·J P BenoitP Menei
Nov 3, 2001·Brain Research. Brain Research Reviews·A D ZurnP Aebischer
Apr 13, 2002·Neuroscience Letters·Anthony P NicholasThomas R Tice
Mar 6, 2003·Journal of Controlled Release : Official Journal of the Controlled Release Society·Jean-Charles BensadounPatrick Aebischer
Jul 29, 2003·Journal of Pharmaceutical Sciences·Karen FuRobert Langer
Mar 1, 1964·The Journal of Surgical Research·J FOLKMAN, D M LONG
Jan 30, 2004·Nature Neuroscience·Deniz KirikAnders Björklund
Feb 1, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·Betül AricaA Atilla Hincal

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Citations

Mar 21, 2009·Journal of Materials Science. Materials in Medicine·Qianru HeFei Ding
Sep 26, 2013·Journal of Drug Delivery·Dharani Manickavasagam, Moses O Oyewumi
Jun 17, 2014·International Journal of Molecular Sciences·Francisca S Y WongAmy C Y Lo
Feb 6, 2008·Expert Opinion on Drug Delivery·Giovanni TosiMaria Angela Vandelli
Oct 26, 2011·Journal of Drug Targeting·Mohammad FazilJaved Ali
Jan 11, 2016·Acta Neurologica Scandinavica·A E Pen, U B Jensen
Nov 17, 2009·Advanced Drug Delivery Reviews·Ho Lun WongReina Bendayan
Jun 3, 2009·Progress in Neurobiology·Girish ModiDinesh Naidoo
Jun 2, 2009·International Journal of Pharmaceutics·Xiaowei LuXirong Guo
Dec 19, 2008·Nanomedicine : Nanotechnology, Biology, and Medicine·Tessy LopezXim Bokhimi
Jul 1, 2008·Progress in Neurobiology·Tomas DeierborgPatrik Brundin
Apr 13, 2007·Journal of Controlled Release : Official Journal of the Controlled Release Society·S KoenningsA Goepferich
Jan 30, 2007·Progress in Neurobiology·Neha SinghYahya E Choonara
Sep 10, 2008·Journal of Biomedical Materials Research. Part a·Xin TangXiaosong Gu
Feb 12, 2010·Annals of the New York Academy of Sciences·Girish ModiYahya E Choonara
Jul 6, 2016·Frontiers in Bioengineering and Biotechnology·Darya Hadavi, André A Poot
Jun 29, 2010·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Farhid Farahmand GhaviMohammad Farhadi
Aug 6, 2009·Nature Reviews. Neuroscience·Gorka OriveDwaine F Emerich
May 31, 2019·Nanoscale Research Letters·Simon D AndersonChristopher D Gwenin
Dec 27, 2011·The International Journal of Artificial Organs·Carmen GiordanoAlberto Cigada
Sep 3, 2017·Journal of Dental Education·Peter J Polverini, Paul H Krebsbach
Apr 24, 2020·Current Pharmaceutical Design·Anmol DograJasjeet K Narang
May 4, 2018·Neural Regeneration Research·Buket Ucar, Christian Humpel
Aug 12, 2018·Nanoscale Research Letters·Khwaja Salahuddin SiddiqiMensur Osman Yassin
Dec 13, 2019·Frontiers in Cellular Neuroscience·Si Yun Ng, Alan Yiu Wah Lee
Mar 14, 2008·Molecular Cancer Research : MCR·Vega García-EscuderoMarta Izquierdo
Dec 10, 2020·International Journal of Molecular Sciences·Haider ManzarM Francesca Cordeiro
Aug 21, 2021·Drug Delivery and Translational Research·Allen B Tu, Jamal S Lewis

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