Therapeutic Potential of DNA-aptamers Raised Against AGE-RAGE Axis in Diabetes-related Complications

Current Pharmaceutical Design
S Yamagishi, Takanori Matsui

Abstract

Accumulating evidence has indicated that formation and accumulation of advanced glycation end products (AGEs) progress under diabetic conditions, thereby contributing to the development and progression of various diabetes- and aging-related disorders, such as diabetic nephropathy, diabetic retinopathy, atherosclerotic cardiovascular disease, insulin resistance, cancer growth and metastasis, osteoporosis, and Alzheimer's disease. Modification of proteins, lipids and nucleic acids by AGEs alter their structural integrity and function, and evoke oxidative stress generation and inflammatory reactions through the interaction with a receptor for AGEs (RAGE), being involved in the above-mentioned devastating disorders. These observations suggest that inhibition of the AGE-RAGE axis is a novel therapeutic target for diabetes- and aging-related complications. Aptamers are short single-stranded RNA or DNA oligonucleotides that can bind to numerous types of proteins with high specificity and affinity, and some type of aptamer raised against vascular endothelial growth factor has been approved for the treatment of patients with neovascular age-related macular degeneration. Since aptamers can be easily generated and highly penetrated into v...Continue Reading

Citations

Mar 21, 2019·Current Pharmaceutical Design·Sho-Ichi YamagishiMinoru Yagi
Aug 2, 2019·Circulation Journal : Official Journal of the Japanese Circulation Society·Sho-Ichi Yamagishi
Mar 25, 2020·Medicina·Massimo De MartinisCarmen Mannucci
Sep 17, 2020·Critical Reviews in Biochemistry and Molecular Biology·Nitish JangdeVivek Rai
May 1, 2020·European Heart Journal·Ulf LandmesserThomas F Lüscher
Jun 14, 2019·Oxidative Medicine and Cellular Longevity·Rosa VonaDonatella Pietraforte
Oct 1, 2019·Journal of Oncology·Nobutaka NakamuraSho-Ichi Yamagishi
Jun 11, 2020·Journal of Clinical Medicine·Pilar SanchisLuis Masmiquel
Mar 12, 2019·Mini Reviews in Medicinal Chemistry·Sho-Ichi YamagishiTakanori Matsui
Feb 5, 2021·Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease·Ami SotokawauchiSho-Ichi Yamagishi
Jan 10, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Kuniyoshi KasedaSho-Ichi Yamagishi
Jul 3, 2021·International Journal of Molecular Sciences·Hyeon Jin KimSe Bok Jang
Aug 21, 2021·Oxidative Medicine and Cellular Longevity·Yoshinori KogaSho-Ichi Yamagishi

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