Therapeutic potential of extracellular vesicles derived from human mesenchymal stem cells in a model of progressive multiple sclerosis

PloS One
Fernando Laso-GarcíaMaría Gutiérrez-Fernández

Abstract

Extracellular vesicles (EVs) have emerged as important mediators of intercellular communication and as possible therapeutic agents in inflammation-mediated demyelinating diseases, including multiple sclerosis (MS). In the present study, we investigated whether intravenously administered EVs derived from mesenchymal stem cells (MSCs) from human adipose tissue might mediate recovery in Theiler's murine encephalomyelitis virus (TMEV)-induced demyelinating disease, a progressive model of MS. SJL/J mice were subjected to EV treatment once the disease was established. We found that intravenous EV administration improved motor deficits, reduced brain atrophy, increased cell proliferation in the subventricular zone and decreased inflammatory infiltrates in the spinal cord in mice infected with TMEV. EV treatment was also capable of modulating neuroinflammation, given glial fibrillary acidic protein and Iba-1 staining were reduced in the brain, whereas myelin protein expression was increased. Changes in the morphology of microglial cells in the spinal cord suggest that EVs also modulate the activation state of microglia. The clear reduction in plasma cytokine levels, mainly in the Th1 and Th17 phenotypes, in TMEV mice treated with EVs c...Continue Reading

References

Sep 28, 2000·The New England Journal of Medicine·J H NoseworthyB G Weinshenker
Dec 28, 2002·Springer Seminars in Immunopathology·Ikuo Tsunoda, Robert S Fujinami
Jan 30, 2008·Current Protocols in Cell Biology·Clotilde ThéryAled Clayton
Jun 19, 2008·Annual Review of Neuroscience·Bruce D Trapp, Klaus-Armin Nave
Oct 17, 2008·Journal of Neuroinflammation·Gwendolyn E GoingsFrancis G Szele
Oct 31, 2008·Lancet·Alastair Compston, Alasdair Coles
Apr 3, 2009·Brain : a Journal of Neurology·Josa M FrischerHans Lassmann
Jul 24, 2010·British Journal of Pharmacology·Carol KilkennyUNKNOWN NC3Rs Reporting Guidelines Working Group
Oct 16, 2010·Progress in Neurobiology·Ranjan Dutta, Bruce D Trapp
Jul 16, 2013·Journal of Autoimmunity·Manu Rangachari, Vijay K Kuchroo
Nov 15, 2014·Stroke; a Journal of Cerebral Circulation·Jaime Ramos-CejudoExuperio Díez-Tejedor
Dec 17, 2014·Molecular Neurobiology·Arian Aryani, Bernd Denecke
Jan 30, 2015·Journal of Neurochemistry·Juan Pablo de Rivero VaccariRobert W Keane
Apr 1, 2015·European Journal of Pharmacology·Claudio ProcacciniGiuseppe Matarese
Apr 22, 2015·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·M Mateo Paz SoldánAaron J Johnson
Apr 23, 2015·Journal of Extracellular Vesicles·Oscar P B WiklanderSamir El Andaloussi
Jun 20, 2015·Stem Cell Research & Therapy·Laura Otero-OrtegaExuperio Díez-Tejedor
Jul 2, 2015·Stem Cell Research & Therapy·Serena Rubina BaglioD Michiel Pegtel
Jul 3, 2015·Expert Opinion on Emerging Drugs·Michael Chopp, Zheng Gang Zhang
Aug 27, 2015·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Richard M RansohoffAmit Bar-Or
Feb 11, 2016·International Journal of Molecular Sciences·Nunzio IraciStefano Pluchino
Jul 5, 2016·Pharmacology & Therapeutics·M MechaC Guaza
Mar 17, 2017·Scientific Reports·Laura Otero-OrtegaMaría Gutiérrez-Fernández
May 20, 2017·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Laura Otero-OrtegaMaría Gutiérrez-Fernández
Jul 29, 2017·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ana FeliúCarmen Guaza
Jan 10, 2018·Journal of Neuroinflammation·Jing Jing LiFrancesca-Fang Liao
Apr 20, 2018·Stroke; a Journal of Cerebral Circulation·Jieli Chen, Michael Chopp
Apr 21, 2018·Annual Review of Immunology·Valentin A PavlovKevin J Tracey

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Citations

Jan 23, 2020·Journal of Clinical Medicine·Ruxandra I SavaKeith L March
Feb 29, 2020·Journal of Leukocyte Biology·Federica MaioneAnnalisa Chiocchetti
May 28, 2020·Pharmaceutics·Carl Randall HarrellVladislav Volarevic
Mar 14, 2019·Current Opinion in Neurology·David KremerPatrick Küry
Aug 8, 2019·International Journal of Molecular Sciences·Yoojin SeoHyung-Sik Kim
Mar 28, 2019·Frontiers in Neurology·Oh Young Bang, Eun Hee Kim
Jul 3, 2020·Frontiers in Cell and Developmental Biology·Helena S DominguesFábio G Teixeira
Jan 10, 2019·Molecular Biology Reports·Fariba RadMehryar Habibi Roudkenar
Jun 20, 2019·Frontiers in Immunology·Moncef Zouali, Antonio La Cava
Mar 12, 2019·Frontiers in Cellular Neuroscience·Alfonso GrimaldiMyriam Catalano
Sep 17, 2020·Stem Cell Reviews and Reports·Xiaoli QianLisha Li
Feb 6, 2020·Immunological Investigations·Morteza JafariniaMazdak Ganjalikhani-Hakemi
Jun 30, 2019·Biochemical Pharmacology·Davide MarangonDavide Lecca
Aug 26, 2019·Allergology International : Official Journal of the Japanese Society of Allergology·He LiWenru Su
Oct 23, 2019·Epilepsy & Behavior : E&B·Dinesh Upadhya, Ashok K Shetty
Nov 21, 2020·International Journal of Molecular Sciences·Agnese GugliandoloEmanuela Mazzon
Mar 20, 2021·Stem Cell Research & Therapy·Alexander MarkovAli Hassanzadeh
Apr 3, 2021·Frontiers in Cell and Developmental Biology·Angeles Fernandez-GonzalezStella Kourembanas
May 16, 2021·Advanced Drug Delivery Reviews·Viridiane GratpainAnne des Rieux
Jul 3, 2021·Biomolecules·Anna Trzyna, Agnieszka Banaś-Ząbczyk
Jul 17, 2021·Neurobiology of Disease·Samantha L Reed, Andrew Escayg
Jul 27, 2021·Frontiers in Cell and Developmental Biology·Jayden A SmithStefano Pluchino
Aug 28, 2021·International Journal of Molecular Sciences·Domenico Nuzzo, Pasquale Picone
Aug 28, 2021·International Journal of Molecular Sciences·María Gutiérrez-FernándezLaura Otero-Ortega
Jul 1, 2020·Current Stem Cell Research & Therapy·Tahereh EbrahimiSoheila Montazersaheb

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Methods Mentioned

BETA
electron microscopy
FCS
ELISA
enzyme-linked immunosorbent assay

Software Mentioned

Pro Plus
Image
Image J
LEICA LAS AF
Leica
MILLIPLEX Analyst
GraphPad
LAS AF
SPSS statistics

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