Therapeutic Potential of Extracellular Vesicles for the Treatment of Corneal Injuries and Scars.

Translational Vision Science & Technology
Sophie X DengSerina Gee

Abstract

Infection, trauma, and chemical exposure of the ocular surface can severely damage the cornea, resulting in visually significant stromal scars. Current medical treatments are ineffective in mitigating corneal scarring, and corneal transplantation is the only therapy able to restore vision in these eyes. However, because of a severe shortage of corneal tissues, risks of blinding complications associated with corneal transplants, and a higher rate of graft failure in these eyes, an effective and deliverable alternative therapy for the prevention and treatment of corneal scarring remains a significant unmet medical need globally. In recent years, the therapeutic potential of extracellular vesicles (EVs) secreted by cells to mediate cell-cell communication has been a topic of increasing interest. EVs derived from mesenchymal stem cells, in particular human corneal stromal stem cells, have antifibrotic, anti-inflammatory, and regenerative effects in injured corneas. The exact mechanism of action of these functional EVs are largely unknown. Therapeutic development of EVs is at an early stage and warrants further preclinical studies.

References

May 1, 1997·Survey of Ophthalmology·Y SolbergM Belkin
Apr 7, 1999·Progress in Retinal and Eye Research·J V JesterH D Cavanagh
Jan 3, 2001·Experimental Eye Research·J D ZieskeA E Hutcheon
Feb 19, 2003·Experimental Eye Research·Rahul R MohanSteven E Wilson
Nov 24, 2004·The International Journal of Developmental Biology·James D Zieske
Jul 30, 2005·Stem Cells·Yiqin DuJames L Funderburgh
May 6, 2006·The International Journal of Biochemistry & Cell Biology·Judith A West-Mays, Dhruva J Dwivedi
Jun 12, 2009·Cutaneous and Ocular Toxicology·Hassan GhasemiZuhair Mohammad Hassan
Apr 27, 2010·Experimental Eye Research·Flavia L BarbosaSteven E Wilson
Jul 6, 2010·Experimental Eye Research·John R Hassell, David E Birk
Aug 3, 2010·The British Journal of Ophthalmology·Radhika TandonRasik B Vajpayee
Jul 14, 2011·Experimental Eye Research·Mariko MatsubaJames D Zieske
Oct 5, 2011·Progress in Retinal and Eye Research·Rajiv R MohanAshish Tandon
Dec 3, 2011·The British Journal of Ophthalmology·Donatella Pascolini, Silvio Paolo Mariotti
Apr 3, 2012·Investigative Ophthalmology & Visual Science·Craig BooteKeith M Meek
Jan 30, 2013·Biochemical Society Transactions·Giovanni CamussiVincenzo Cantaluppi
Feb 20, 2013·The Journal of Cell Biology·Graça Raposo, Willem Stoorvogel
May 23, 2013·Investigative Ophthalmology & Visual Science·Andre A M TorricelliSteven E Wilson
Oct 2, 2013·Oman Journal of Ophthalmology·Parul SinghP D Sharma
Aug 12, 2014·Journal of Ophthalmology·Medi EslaniAli R Djalilian
Dec 17, 2014·Science Translational Medicine·Sayan BasuJames L Funderburgh
May 17, 2015·Journal of Extracellular Vesicles·María Yáñez-MóOlivier De Wever
Dec 4, 2015·JAMA Ophthalmology·Philippe GainGilles Thuret
Dec 18, 2015·Experimental Eye Research·Andre A M TorricelliSteven E Wilson
May 21, 2016·Molecular Therapy : the Journal of the American Society of Gene Therapy·Bo WangSharon D Ricardo
May 24, 2016·Journal of Functional Biomaterials·Borja Salvador-Culla, Paraskevi E Kolovou
Jun 17, 2016·Annals of the New York Academy of Sciences·Patrick M McNuttTracey A Hamilton
Aug 5, 2016·JAMA Ophthalmology·R Sterling HaringEric B Schneider
Sep 2, 2016·Stem Cell Research & Therapy·Jeffrey L SpeesCarl A Gregory
Nov 9, 2016·Scientific Reports·Steffi BoschJean-Marie Bach
Jan 24, 2017·DNA and Cell Biology·Yuan ZhangQian Wang
Mar 16, 2017·Stem Cells·Donald G Phinney, Mark F Pittenger
Mar 25, 2017·PloS One·Suneel GuptaRajiv R Mohan
Jun 20, 2017·Matrix Biology : Journal of the International Society for Matrix Biology·Steven E WilsonCarla S Medeiros
Oct 28, 2017·Investigative Ophthalmology & Visual Science·Medi EslaniAli R Djalilian

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Citations

Feb 12, 2021·Experimental Eye Research·Clémence BonnetSophie X Deng
Mar 7, 2021·Progress in Retinal and Eye Research·Clémence BonnetSophie X Deng
Aug 3, 2021·Analytical Cellular Pathology (Amsterdam)·Tina B McKayJoseph B Ciolino

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NCT02948023
NCT03295292

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