Therapeutic potential of ginger against renal injury induced by carbon tetrachloride in rats.

TheScientificWorldJournal
Manal A HamedNagy Saba El-Rigal

Abstract

The objective of this study was to evaluate the potential of successive ginger extracts (petroleum ether, chloroform, and ethanol) against nephrotoxicity induced by CCl(4) in rats. The evaluation was done through measuring kidney antioxidant parameters: glutathione (GSH), lipid peroxides (LPO), and superoxide dismutase (SOD). Renal function test: urea, creatinine and serum protein values, were also evaluated. The work was extended to examine tissue inflammatory mediators, prostaglandin-E(2) (PGE(2)), collagen content and the kidney histopathology. Severe alterations in all biomarkers were observed after injury with CCl(4). Treatment with ginger extracts resulted in markedly decreased levels of LPO, PGE(2), collagen and kidney function tests, while increased levels of GSH, SOD and serum protein were observed. In conclusion, extracts of ginger, particularly the ethanol, resulted in an attractive candidate for the treatment of nephropathy induced by CCl(4) through scavenging free radicals, improved kidney functions, inhibition of inflammatory mediators, and normalizing the kidney histopathological architecture. Further studies are required in order to identify the molecules responsible of the pharmacological activity.

References

Jan 1, 1978·Methods in Enzymology·J A Buege, S D Aust
Jan 31, 1972·Biochemical and Biophysical Research Communications·M NishikimiK Yagi
Mar 1, 1971·Clinica Chimica Acta; International Journal of Clinical Chemistry·H Bartels, M Böhmer
Nov 1, 1995·Medical Hypotheses·E P Cohen
Feb 25, 2000·Matrix Biology : Journal of the International Society for Matrix Biology·M A HaralsonR C Harris
Jul 31, 2002·Biochemical Pharmacology·Mohammed Ali Al-BayatiShri N Giri
Feb 1, 1962·Archives of Biochemistry and Biophysics·S E KERR, G A KFOURY
Feb 15, 2005·Journal of Ethnopharmacology·M OgeturkM Sarsilmaz
May 27, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Sathish Kumar NatarajanKunissery A Balasubramanian
May 6, 2008·Biochimica Et Biophysica Acta·Jean-Philippe PradèreJoost P Schanstra
Jul 1, 2008·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·R SmythM R Munday
Aug 6, 2008·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·T A AjithU Hema
Sep 1, 2007·Pakistan Journal of Biological Sciences : PJBS·Modaresi MehrdadMozhgan Ghobadipour
Jan 3, 2009·Journal of Ethnopharmacology·Muhammad R KhanSaima Shaheen
Mar 31, 2009·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Muhammad Rashid Khan, Dawood Ahmed
Apr 18, 2009·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·A S El-SharakyS M Eweda
May 22, 2009·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Ali A Shati, Fahmy G Elsaid
Aug 11, 2009·Journal of Basic and Clinical Physiology and Pharmacology·P Yuvaraj, A Subramoniam
Jan 26, 2010·Journal of Agricultural and Food Chemistry·Chin-Lin HsuGow-Chin Yen
Feb 12, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Rikke NørregaardJørgen Frøkiaer
Mar 3, 2010·Ultrastructural Pathology·Shaila R KhubchandaniSwarnalata Gowrishankar
Jun 17, 2010·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Rahmat Ali KhanJasia Bokhari
Jul 9, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Inge CarlsenRikke Nørregaard
Dec 15, 2010·European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes·S MaghsoudiA Javadi
Jun 22, 2011·Nutrition & Metabolism·Tarek K MotawiAsmaa F Aboul Naser

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Citations

Feb 20, 2013·Journal of Dietary Supplements·Souad E El-GengaihiMona A Mohammed
Dec 5, 2015·Journal of Dietary Supplements·Abd El-Rahman M Khalaf-AllahMona A Mohammed
Jul 1, 2014·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Jie-Qiong MaChan-Min Liu
Dec 20, 2017·Journal of Feline Medicine and Surgery·Melissa DanielsAmanda J Callens
Jan 8, 2014·Antimicrobial Agents and Chemotherapy·Francisco A P RodriguesAlexandre Havt
Apr 14, 2019·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Abdelgawad FahmiEngy Shams-Eldin
Dec 19, 2017·Journal of Neurology, Neurosurgery, and Psychiatry·Eleanor KingAlan J Thomas
Oct 31, 2013·Journal of Dietary Supplements·Souad E El-GengaihiMona A Mohammed
Jun 1, 2017·Metabolic Brain Disease·Tarek K MotawiAsmaa F Aboul Naser
Sep 8, 2017·Apoptosis : an International Journal on Programmed Cell Death·Jing YuZhanjun Jia
Aug 16, 2018·Scientific Reports·Francisco Adelvane de Paulo RodriguesAlexandre Havt
Aug 22, 2015·Human & Experimental Toxicology·Smeo Elmubarak, N Özsoy
Jul 28, 2016·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Chun-De LiaoLi-Fong Lin
Feb 6, 2017·Indian Journal of Clinical Biochemistry : IJCB·Walaa Arafa Keshk, Mohamed Alaa Katary
Oct 28, 2019·Regional Anesthesia and Pain Medicine·Kelsey D MitchellGrace Lim
May 9, 2021·BMJ Case Reports·Kanyada KoysombatFarzad Borumandi
May 16, 2021·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Sadie Esme Fleur JonesAarti Sharma
Jul 22, 2021·European Journal of Hospital Pharmacy. Science and Practice·Nyein Hsu MaungTatta Sriboonruang
Jul 4, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Amir M Al HroobAyman M Mahmoud
Nov 4, 2021·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Wessam M AzizSamia A Ahmed

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