Therapeutic Potential of Ginsenosides as an Adjuvant Treatment for Diabetes

Frontiers in Pharmacology
Litao BaiJunping Wei

Abstract

Ginseng, one of the oldest traditional Chinese medicinal herbs, has been used widely in China and Asia for thousands of years. Ginsenosides extracted from ginseng, which is derived from the roots and rhizomes of Panax ginseng C. A. Meyer, have been used in China as an adjuvant in the treatment of diabetes mellitus. Owing to the technical complexity of ginsenoside production, the total ginsenosides are generally extracted. Accumulating evidence has shown that ginsenosides exert antidiabetic effects. In vivo and in vitro tests revealed the potential of ginsenoside Rg1, Rg3, Rg5, Rb1, Rb2, Rb3, compound K, Rk1, Re, ginseng total saponins, malonyl ginsenosides, Rd, Rh2, F2, protopanaxadiol (PPD) and protopanaxatriol (PPT)-type saponins to treat diabetes and its complications, including type 1 diabetes mellitus, type 2 diabetes mellitus, diabetic nephropathy, diabetic cognitive dysfunction, type 2 diabetes mellitus with fatty liver disease, diabetic cerebral infarction, diabetic cardiomyopathy, and diabetic erectile dysfunction. Many effects are attributed to ginsenosides, including gluconeogenesis reduction, improvement of insulin resistance, glucose transport, insulinotropic action, islet cell protection, hepatoprotective activity...Continue Reading

References

Jan 1, 1977·The American Journal of Chinese Medicine·S Y Hu
Nov 14, 2000·Trends in Neurosciences·W H Gispen, G J Biessels
May 3, 2001·The New England Journal of Medicine·J TuomilehtoUNKNOWN Finnish Diabetes Prevention Study Group
Oct 17, 2001·The Journal of Clinical Investigation·G ZhouD E Moller
Jan 24, 2002·American Journal of Physiology. Gastrointestinal and Liver Physiology·J DyerS P Shirazi-Beechey
Jan 31, 2003·Cardiovascular Diabetology·Christophe BautersPascal de Groote
Mar 5, 2003·Journal of Biochemical and Molecular Toxicology·A C MaritimJ B Watkins
Jun 6, 2003·The New England Journal of Medicine·David M NathanUNKNOWN Epidemiology of Diabetes Interventions and Complications Research Group
Oct 16, 2004·Science·Umut OzcanGökhan S Hotamisligil
Mar 15, 2006·Lancet·Denis Daneman
Jun 27, 2006·Journal of Ethnopharmacology·William C S ChoKevin K M Yue
Aug 8, 2006·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·H NoguchiS Matsumoto
Sep 8, 2006·Clinica Chimica Acta; International Journal of Clinical Chemistry·Barbara MlinarMarija Pfeifer
Mar 1, 2007·Diabetes Care·David M NathanUNKNOWN American Diabetes Association
May 22, 2007·Journal of Hepatology·Isabelle A LeclercqAlbert Geerts
Sep 12, 2007·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·P M CampbellA M J Shapiro
Aug 30, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Anna Ludovica FracanzaniSilvia Fargion
May 7, 2009·Cell Metabolism·Bei B ZhangCai Li
Oct 13, 2009·Molecular Biology Reports·Hai-xiang NiXue-hui Yang
Mar 26, 2010·The New England Journal of Medicine·Wenying YangUNKNOWN China National Diabetes and Metabolic Disorders Study Group
Jun 12, 2010·Chinese Medicine·Kar Wah Leung, Alice Sze-Tsai Wong
Nov 8, 2011·Journal of Nephrology·Ankur GuptaMohan Biyani
Jun 12, 2012·Lancet·Rory J McCrimmonBrian M Frier
Jul 10, 2012·Trends in Endocrinology and Metabolism : TEM·Mélissa FlammentFabienne Foufelle
Sep 5, 2013·JAMA : the Journal of the American Medical Association·Yu XuUNKNOWN 2010 China Noncommunicable Disease Surveillance Group
Sep 18, 2013·Diabetes, Obesity & Metabolism·D RondasC Mathieu
Nov 16, 2013·Journal of Ginseng Research·Ki Sung KangNoriko Yamabe
Jan 1, 2014·Progress in Molecular Biology and Translational Science·Prashant NadkarniGeorge G Holz

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Citations

Aug 24, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Chao HongJianxin Wang
Jan 29, 2019·The American Journal of Hospice & Palliative Care·Mellar P Davis, Bertrand Behm
Dec 15, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Wei ChenDavid G Popovich
Jun 18, 2020·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Wei FuHongwei Jiang
Dec 29, 2018·International Journal of Molecular Sciences·Aikaterini G KarraAnna-Maria G Psarra
Jul 2, 2019·Frontiers in Pharmacology·Jun LiJunping Wei
Oct 21, 2019·Chinese Journal of Integrative Medicine·Xiang-Yan LiDa-Qing Zhao
Apr 24, 2020·Frontiers in Neuroscience·Shawn D FlanaganWilliam J Kraemer
Mar 10, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Nur Shafika Mohd Sairazi, K N S Sirajudeen
Sep 29, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Wei ChenDavid G Popovich
May 18, 2020·Chinese Journal of Integrative Medicine·Rui-Lin LiShao-Xia Wang
May 6, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Nam-Hui YimHwan-Suck Chung
Jan 8, 2021·International Immunopharmacology·Cheng YangWenxiang Huang
Dec 29, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Ying ZhuJianxin Wang
Dec 10, 2020·Journal of Intensive Care·Woo Hyun ChoHye Ju Yeo
Mar 4, 2021·International Journal of Molecular Sciences·Joo-Hee LeeSeung-Hoon Yang
Jul 9, 2021·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Mingyue HuangDan Yan
Jul 25, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mayadah Bashir ShehadehAla' Mustafa Abu-Odeh
Nov 1, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Hanbing LiuXiaohui Fan
Jun 22, 2021·Experimental and Therapeutic Medicine·Ming-Yang LiuHai-Jun Li
Aug 14, 2021·Acta Pharmaceutica Sinica. B·Maoqi HouZhengtao Wang
Aug 14, 2021·Sexual Medicine·Nelisiwe Prenate MasukuSogolo Lucky Lebelo
May 18, 2020·Current Diabetes Reviews·Neeraj ChoudharyAshish Suttee

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