PMID: 18411128May 1, 1990Paper

Therapeutic potential of insulinlike growth factor i

Trends in Endocrinology and Metabolism : TEM
E R FroeschJ Zapf

Abstract

Human recombinant insulinlike growth factor I is a promising therapeutic agent for diseases characterized by relative insulin resistance, e.g., diabetes mellitus, obesity, and hypertriglyceridemia, since it suppresses growth hormone, insulin, C-peptide, and triglyceride levels and lowers the total cholesterol to high-density lipoprotein-cholesterol ratio. Moreover, insulinlike growth factor administration increases kidney function in healthy subjects (glomerular filtration rate, renal plasma flow) and may prove useful in the treatment of degenerative disorders of cartilage and bone (arthrosis, osteoporosis) as well as in catabolic states.

References

Jun 1, 1975·Archives of Biochemistry and Biophysics·J ZapfE R Froesch
Jan 1, 1977·The Journal of Clinical Endocrinology and Metabolism·U KaufmannE R Froesch
Jan 1, 1989·Progress in Growth Factor Research·R C Baxter, J L Martin
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Jul 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·H P GulerE R Froesch
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Mar 1, 1984·Clinics in Endocrinology and Metabolism·L S Phillips, T G Unterman

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Citations

Oct 1, 1992·Diabetes/metabolism Reviews·L A Bach, M M Rechler
May 20, 1998·Baillière's Clinical Endocrinology and Metabolism·C BotfieldC J Hinds
Sep 15, 2000·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·H L SimpsonD L Russell-Jones
Oct 14, 2003·Bone·Lorenz MeinelBrigitte von Rechenberg
Nov 1, 1992·Clinical Endocrinology·R C CuneoP H Sönksen
Dec 1, 1993·Journal of Internal Medicine·A G JohanssonS Ljunghall
Jul 1, 1995·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·J D KoppleX L Gao
Sep 13, 2000·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·L Vinter-JensenE Nexø
Jul 18, 2014·Endocrinology and Metabolism·Si Won LeeEun Kyung Hong
Nov 9, 1991·BMJ : British Medical Journal·R J RossC R Buchanan
Aug 1, 1993·Journal of the American College of Nutrition·K K HillC J McClain
Feb 1, 1995·The Annals of Pharmacotherapy·T W MattoxP G Cuddy

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