Therapeutic Potential of Mesenchymal Stem Cell-Derived Exosomes in the Treatment of Eye Diseases

Advances in Experimental Medicine and Biology
C Randall HarrellVladislav Volarevic

Abstract

Mesenchymal stem cells (MSCs) were, due to their immunomodulatory and pro-angiogenic characteristics, extensively explored as new therapeutic agents in cell-based therapy of uveitis, glaucoma, retinal and ocular surface diseases.Since it was recently revealed that exosomes play an important role in biological functions of MSCs, herewith we summarized current knowledge about the morphology, structure, phenotype and functional characteristics of MSC-derived exosomes emphasizing their therapeutic potential in the treatment of eye diseases.MSC-derived exosomes were as efficient as transplanted MSCs in limiting the extent of eye injury and inflammation. Immediately after intravitreal injection, MSC-derived exosomes, due to nano-dimension, diffused rapidly throughout the retina and significantly attenuated retinal damage and inflammation. MSC-derived exosomes successfully delivered trophic and immunomodulatory factors to the inner retina and efficiently promoted survival and neuritogenesis of injured retinal ganglion cells. MSC-derived exosomes efficiently suppressed migration of inflammatory cells, attenuated detrimental Th1 and Th17 cell-driven immune response and ameliorated experimental autoimmune uveitis. MSC-derived exosomes we...Continue Reading

Citations

May 16, 2019·American Journal of Physiology. Cell Physiology·Stefania BrunoGiovanni Camussi
May 28, 2020·Pharmaceutics·Carl Randall HarrellVladislav Volarevic
Jun 26, 2020·Frontiers in Bioengineering and Biotechnology·Pei JiangRenjie Chai
Aug 29, 2020·International Journal of Molecular Sciences·Natalie LernerElie Beit-Yannai
Jan 18, 2020·Stem Cells International·C Randall HarrellVladislav Volarevic
Apr 4, 2019·Molecular Neurobiology·Eliana Baez-JuradoGeorge E Barreto
Sep 17, 2020·Stem Cell Reviews and Reports·Xiaoli QianLisha Li
Jan 23, 2021·International Journal of Molecular Sciences·José A CañasVictoria del Pozo
Jan 7, 2021·International Journal of Nanomedicine·Jia LiuZhuhong Zhang
Feb 9, 2021·Frontiers in Cell and Developmental Biology·Baraa NoueihedSylvain Chemtob
Feb 27, 2021·International Ophthalmology·Uwe PleyerChristoph Deuter
Apr 26, 2020·IScience·Adriana-Natalia MurgociMichel Salzet
Jun 5, 2021·Experimental Eye Research·Zhihan ZhangMin Fu

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