Therapeutic potential of nutraceuticals to protect brain after stroke.

Neurochemistry International
Bharath Chelluboina, Raghu Vemuganti

Abstract

Stroke leads to significant neuronal death and long-term neurological disability due to synergistic pathogenic mechanisms. Stroke induces a change in eating habits and in many cases, leads to undernutrition that aggravates the post-stroke pathology. Proper nutritional regimen remains a major strategy to control the modifiable risk factors for cardiovascular and cerebrovascular diseases including stroke. Studies indicate that nutraceuticals (isolated and concentrated form of high-potency natural bioactive substances present in dietary nutritional components) can act as prophylactic as well as adjuvant therapeutic agents to prevent stroke risk, to promote ischemic tolerance and to reduce post-stroke consequences. Nutraceuticals are also thought to regulate blood pressure, delay neurodegeneration and improve overall vascular health. Nutraceuticals potentially mediate these effects by their powerful antioxidant and anti-inflammatory properties. This review discusses the studies that have highlighted the translational potential of nutraceuticals as stroke therapies.

References

May 1, 1995·Stroke; a Journal of Cerebral Circulation·S SasakiH Kesteloot
Apr 14, 1994·The New England Journal of Medicine·UNKNOWN Alpha-Tocopherol, Beta Carotene Cancer Prevention Study Group
May 2, 1996·The New England Journal of Medicine·G S OmennS Hammar
May 23, 1996·The New England Journal of Medicine·H S Friedman
May 22, 1998·Stroke; a Journal of Cerebral Circulation·H B van der WorpD J de Wildt
Jan 8, 2000·Stroke; a Journal of Cerebral Circulation·J S LeinonenH Alho
Sep 27, 2002·QJM : Monthly Journal of the Association of Physicians·S E GariballaA J Sinclair
Mar 18, 2003·Developmental Neuroscience·Kathryn H AdcockBendicht P Wagner
Apr 12, 2003·Stroke; a Journal of Cerebral Circulation·Jaroslaw AronowskiJames C Grotta
May 3, 2003·Nature Reviews. Neuroscience·Eng H LoMichael A Moskowitz
Jul 29, 2004·Clinical Science·Rajesh UllegaddiSalah E Gariballa
Mar 17, 2005·JAMA : the Journal of the American Medical Association·Eva LonnUNKNOWN HOPE and HOPE-TOO Trial Investigators
Jun 10, 2005·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Warren K Laskey
Sep 17, 2005·Stroke; a Journal of Cerebral Circulation·Savita KhannaChandan K Sen
Sep 28, 2005·Circulation·Patrick StaatMichel Ovize
Nov 29, 2005·Journal of Bioscience and Bioengineering·Jun OgawaSakayu Shimizu
Mar 7, 2006·JPEN. Journal of Parenteral and Enteral Nutrition·Rajesh UllegaddiSalah E Gariballa
Aug 31, 2006·Behavioural Pharmacology·Maciej GasiorAdam L Hartman
Sep 22, 2006·Journal of Alzheimer's Disease : JAD·Laura ZhangMark Rosenthal
Dec 30, 2006·European Journal of Public Health·Ritva PrättäläJanina Petkeviciene
Feb 21, 2007·Circulation·Judith HsiaUNKNOWN Women's Health Initiative Investigators
Apr 3, 2007·Lancet·Mitsuhiro YokoyamaUNKNOWN Japan EPA lipid intervention study (JELIS) Investigators
Apr 7, 2007·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·Gilbert S Omenn
Jul 3, 2007·Experimental & Molecular Medicine·Dae-Soo JungSae-Ock Oh
Sep 11, 2007·Bioscience, Biotechnology, and Biochemistry·Se-Eun ParkSung-Jun Kim
Nov 15, 2007·Molecular Pharmaceutics·Preetha AnandBharat B Aggarwal
Jan 16, 2008·Archives of Neurology·Sung-Hee YooDong-Wha Kang
Apr 12, 2008·Stroke; a Journal of Cerebral Circulation·Hans-Christoph DienerGilad Rosenberg

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Citations

Aug 18, 2021·Neurochemistry International·Robert J WilliamsPhilip M Beart

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