Therapeutic Potential of Oridonin and Its Analogs: From Anticancer and Antiinflammation to Neuroprotection

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Jimin XuJia Zhou

Abstract

Oridonin, a diterpenoid natural product commonly used in East Asian herbal medicine, is garnering increased attention in the biomedical community due to its extensive biological activities that include antitumor, anti-inflammatory, antimicrobial, hepatic fibrosis prevention, and neurological effects. Over the past decade, significant progress has been made in structure activity relationship and mechanism of action studies of oridonin for the treatment of cancer and other diseases. This review provides a brief summary on oridonin and its analogs in cancer drug discovery and antiinflammation and highlights its emerging therapeutic potential in neuroprotection applications.

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Feb 26, 2019·Biotechnology and Applied Biochemistry·Muhammad Torequl IslamMohammad S Mubarak
Jan 17, 2020·Immunological Reviews·Lotte Spel, Fabio Martinon
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