Therapeutic potential of promiscuous targets in Mycobacterium tuberculosis

Current Opinion in Pharmacology
Bei Shi Lee, Kevin Pethe

Abstract

In the field of tuberculosis drug development, the term 'promiscuous' was coined to collectively describe targets that repeatedly show up in whole-cell screenings. With the current climate leaning towards the exclusion of these targets in future drug screens, this review discusses and clarifies misconceptions surrounding this classification, the prospects of developing compounds targeting promiscuous targets, and their potential impact on tuberculosis drug development. The dominance of these targets in cell-based screens reflect not only bias introduced by experimental setup, but also some of the pathogen's greatest vulnerabilities. Coupled with favourable predictions of their in vivo efficacies and synergism with other TB drugs, these targets open opportunities to be explored for the development of rational drug combination for tuberculosis.

Citations

Aug 14, 2019·Antimicrobial Agents and Chemotherapy·John T WilliamsRobert B Abramovitch
Apr 2, 2021·Frontiers in Cellular and Infection Microbiology·Sangmi OhHelena I Boshoff
Jun 5, 2021·RSC Medicinal Chemistry·Katherine A Abrahams, Gurdyal S Besra

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antitubercular Agents

Antitubercular agents are pharmacologic agents for treatment of tuberculosis. Discover the latest research on antitubercular agents here.

Antitubercular Agents (ASM)

Antitubercular agents are pharmacologic agents for treatment of tuberculosis. Discover the latest research on antitubercular agents here.

Related Papers

Cancer Chemotherapy Reports. Part 2
N Mantal
© 2022 Meta ULC. All rights reserved