Therapeutic potential of pyruvate therapy for patients with mitochondrial diseases: a systematic review

Therapeutic Advances in Endocrinology and Metabolism
Min LiYimin Cui

Abstract

Mitochondrial disease is a term used to describe a set of heterogeneous genetic diseases caused by impaired structure or function of mitochondria. Pyruvate therapy for mitochondrial disease is promising from a clinical point of view. According to PRISMA guidelines, the following databases were searched to identify studies regarding pyruvate therapy for mitochondrial disease: PubMed, EMBASE, Cochrane Library, and Clinicaltrials. The search was up to April 2019. The endpoints were specific biomarkers (plasma level of lactate, plasma level of pyruvate, L/P ratio) and clinical rating scales [Japanese mitochondrial disease-rating scale (JMDRS), Newcastle Mitochondrial Disease Adult Scale (NMDAS), and others]. Two researchers independently screened articles, extracted data, and assessed the quality of the studies. A total of six studies were included. Considerable differences were noted between studies in terms of study design, patient information, and outcome measures. The collected evidence may indicate an effective potential of pyruvate therapy on the improvement of mitochondrial disease. The majority of the common adverse events of pyruvate therapy were diarrhea and short irritation of the stomach. Pyruvate therapy with no seriou...Continue Reading

References

Jun 14, 2003·Brain : a Journal of Neurology·Daniela SkladalDavid R Thorburn
Mar 1, 2006·Pediatric Neurology·Manuel Castro-GagoJesús Eirís-Puñal
Nov 25, 2006·Neuromuscular Disorders : NMD·C PhoenixR McFarland
Sep 21, 2007·Mitochondrion·Masashi TanakaYasutoshi Koga
Apr 22, 2009·Pediatric Neurology·Luísa DiogoCatarina Resende Oliveira
Jul 17, 2009·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Olivier Feron
Jul 21, 2009·Biochimica Et Biophysica Acta·Hirofumi KomakiMasashi Tanaka
Jul 22, 2009·PLoS Medicine·David MoherUNKNOWN PRISMA Group
Jun 19, 2010·Molecular and Cellular Biochemistry·K R HegdeShambhu D Varma
Mar 30, 2011·Biochimica Et Biophysica Acta·Shuichi YatsugaUNKNOWN Taro Matsuoka for MELAS Study Group in Japan
Aug 23, 2011·Biochimica Et Biophysica Acta·Keiko SaitoTatsuya Fujii
May 17, 2014·Molecular Genetics and Metabolism·Tatsuya FujiiTomohiro Kumada
Dec 17, 2014·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Sumit ParikhSalvatore DiMauro
Jan 4, 2015·BMJ : British Medical Journal·Larissa ShamseerUNKNOWN PRISMA-P Group
Feb 6, 2015·Annals of Neurology·Gráinne S GormanRobert McFarland
Oct 16, 2015·Annals of Neurology·Shuichi YatsugaYasutoshi Koga
Feb 14, 2016·Trends in Biochemical Sciences·Kristofor A OlsonJared Rutter
Feb 18, 2016·The Journal of Clinical Endocrinology and Metabolism·Takeshi InoueRyoichi Sakuta
Nov 4, 2016·Nature Reviews. Endocrinology·Jasmine ChowShamima Rahman
Oct 14, 2016·BMJ : British Medical Journal·Jonathan Ac SterneJulian Pt Higgins
Mar 2, 2017·Molecular and Cellular Biochemistry·Priscila Ramos-IbeasGiovanna Lazzari
Apr 19, 2017·Annual Review of Genomics and Human Genetics·Lyndsey CravenDoug M Turnbull
Sep 26, 2017·Molecular Genetics and Metabolism·Ayman W El-HattabFernando Scaglia
Nov 22, 2018·Journal of Human Genetics·Kei MurayamaAkira Ohtake
Mar 3, 2020·Redox Biology·George A Brooks

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