Therapeutic potential of self-antigen-specific CD4+ CD25+ regulatory T cells selected in vitro from a polyclonal repertoire

European Journal of Immunology
Sylvain FissonBenoît L Salomon

Abstract

CD4+ CD25+ regulatory T cells (Treg) play a major role in the prevention of autoimmune diseases. Converging evidence indicates that Treg specific for self-antigens expressed by target tissues have a greater therapeutic potential than polyclonal Treg. Therefore, the selective expansion of rare self-antigen-specific T(reg) naturally present in a polyclonal repertoire of Treg is of major importance. In this work, we investigated the potential of different dendritic cell (DC) subsets to expand antigen-specific Treg in mice. The in vitro selective expansion of rare islet-specific Treg from polyclonal Treg could only be achieved efficiently by stimulation with CD8+ splenic DC presenting islet antigens. These islet-specific Treg exerted potent bystander suppression on diabetogenic T cells and prevented type 1 diabetes. This approach opens new perspectives for cell therapy of autoimmune diseases.

References

Dec 22, 1999·The Journal of Immunology : Official Journal of the American Association of Immunologists·A M Thornton, E M Shevach
Dec 20, 2000·The Journal of Experimental Medicine·J M den HaanM J Bevan
May 22, 2002·The Journal of Experimental Medicine·Tomonori IyodaKayo Inaba
May 31, 2002·The New England Journal of Medicine·Kevan C HeroldJeffrey A Bluestone
Aug 7, 2002·The Journal of Experimental Medicine·José L CohenBenoît L Salomon
Aug 24, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Veronika SzanyaC Garrison Fathman
Sep 7, 2002·Human Gene Therapy·Benoît BarrouPatricia Lemarchand
Sep 11, 2002·Proceedings of the National Academy of Sciences of the United States of America·Ava J WuHugh O McDevitt
Oct 23, 2002·The Journal of Experimental Medicine·Gabrielle T BelzWilliam R Heath
Jul 15, 2003·Proceedings of the National Academy of Sciences of the United States of America·Ludger KleinHarald von Boehmer
Jul 23, 2003·The Journal of Experimental Medicine·Sayuri YamazakiRalph M Steinman
Jul 23, 2003·The Journal of Experimental Medicine·Lucy S K WalkerAbul K Abbas
Aug 27, 2003·The Journal of Experimental Medicine·Sylvain FissonBenoît L Salomon
Dec 16, 2003·Proceedings of the National Academy of Sciences of the United States of America·Marie-Alexandra AlyanakianJean-François Bach
Jan 28, 2004·The Journal of Experimental Medicine·Fei F ShihPaul M Allen
May 7, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Stephen P CobboldHerman Waldmann
May 22, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Major K LeeJames F Markmann
Jun 9, 2004·The Journal of Experimental Medicine·Qizhi TangJeffrey A Bluestone
Jun 9, 2004·The Journal of Experimental Medicine·Kristin V TarbellRalph M Steinman
Jun 9, 2004·The Journal of Experimental Medicine·Ann E HermanChristophe Benoist
Jul 29, 2004·The Journal of Experimental Medicine·Clare Baecher-Allan, David A Hafler
Aug 17, 2004·Immunity·Chyi-Song HsiehAlexander Y Rudensky
Oct 7, 2004·Proceedings of the National Academy of Sciences of the United States of America·Hugh McDevitt
Nov 3, 2004·International Immunology·Zoltán Fehérvári, Shimon Sakaguchi
Nov 10, 2004·The Journal of Experimental Medicine·Hisse-Martien van SantenDiane Mathis
Jun 24, 2005·The New England Journal of Medicine·Bart KeymeulenLucienne Chatenoud
Aug 24, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Emma L MastellerJeffrey A Bluestone

❮ Previous
Next ❯

Citations

Jul 29, 2006·Springer Seminars in Immunopathology·Jocelyne DemengeotAntónio Coutinho
Feb 19, 2010·Mucosal Immunology·A RayP Ray
Feb 1, 2007·Molecular Therapy : the Journal of the American Society of Gene Therapy·Christopher W ThomsonLi Zhang
Aug 5, 2009·The Journal of Clinical Investigation·Guillaume Darrasse-JèzeDavid Klatzmann
Nov 26, 2010·The Journal of Clinical Investigation·Yenkel Grinberg-BleyerBenoît L Salomon
Oct 3, 2007·Regenerative Medicine·Georgia FousteriMatthias von Herrath
Aug 9, 2011·Seminars in Immunology·Keli L HippenBruce R Blazar
Feb 7, 2006·Seminars in Immunology·Emma L MastellerJeffrey A Bluestone
Oct 27, 2009·Best Practice & Research. Clinical Rheumatology·Berent J Prakken, Salvatore Albani
Apr 2, 2013·Progress in Retinal and Eye Research·John V ForresterMatthew E Wikstrom
Jan 10, 2008·Trends in Immunology·Dieter KabelitzLucienne Chatenoud
Dec 22, 2006·Journal of Neurochemistry·Cécile Cassan, Roland S Liblau
May 3, 2008·Current Opinion in Neurology·Stephen M Anderton, Roland S Liblau
Mar 31, 2006·European Journal of Immunology·Luis GraçaAntonio Coutinho
Mar 1, 2007·Expert Review of Endocrinology & Metabolism·Christophe M Filippi, Matthias G von Herrath
Jun 15, 2007·International Reviews of Immunology·Yanyan Qu, Yong Zhao
May 6, 2020·The Journal of Immunology : Official Journal of the American Association of Immunologists·Rianne OpsteltenDerk Amsen
Dec 22, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Pascal ChappertDavid-Alexandre Gross
Apr 22, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Asmahan OuabedRégis Josien
Jan 5, 2013·Clinical and Experimental Immunology·A E Barcala TabarrozziM J Perone
Aug 28, 2012·Médecine sciences : M/S·Guilaine BoursierHubert de Boysson
Jan 31, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sylvie GrégoireBenoît L Salomon

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.