Therapeutic Potential of Stem Cells in Follicle Regeneration

Stem Cells International
Agnieszka Owczarczyk-SaczonekJoanna Wojtkiewicz

Abstract

Alopecia is caused by a variety of factors which affect the hair cycle and decrease stem cell activity and hair follicle regeneration capability. This process causes lower self-acceptance, which may result in depression and anxiety. However, an early onset of androgenic alopecia is associated with an increased incidence of the metabolic syndrome and an increased risk of the cardiac ischaemic disease. The ubiquity of alopecia provides an encouragement to seek new, more effective therapies aimed at hair follicle regeneration and neoregeneration. We know that stem cells can be used to regenerate hair in several therapeutic strategies: reversing the pathological mechanisms which contribute to hair loss, regeneration of complete hair follicles from their parts, and neogenesis of hair follicles from a stem cell culture with isolated cells or tissue engineering. Hair transplant has become a conventional treatment technique in androgenic alopecia (micrografts). Although an autologous transplant is regarded as the gold standard, its usability is limited, because of both a limited amount of material and a reduced viability of cells obtained in this way. The new therapeutic options are adipose-derived stem cells and stem cells from Wharto...Continue Reading

References

Feb 14, 1998·The Journal of Clinical Investigation·M C JongL M Havekes
Oct 13, 1998·Current Biology : CB·B St-JacquesA P McMahon
Jan 20, 1999·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·T Matsuzaki, K Yoshizato
Mar 2, 1999·Developmental Biology·S E MillarG S Barsh
Apr 1, 2000·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·K FoitzikR Paus
Apr 20, 2000·The Journal of Investigative Dermatology·L MecklenburgR Paus
May 16, 2000·The British Journal of Dermatology·T ChristophR Paus
Jul 19, 2000·Proceedings of the National Academy of Sciences of the United States of America·J HalloyA Goldbeter
Feb 22, 2001·The Journal of Clinical Investigation·K YanoM Detmar
Jan 21, 2003·Genes & Development·Pleasantine MillChi-chung Hui
Mar 22, 2003·Developmental Biology·Anthony E Oro, Kay Higgins
Jan 13, 2004·Experimental Dermatology·Colin A B JahodaNicholas Hole
Jun 26, 2004·Experimental Dermatology·Maki OzawaHachiro Tagami
Jan 5, 2005·Trends in Immunology·Ralf PausTaisuke Ito
Jan 6, 2006·The Journal of Clinical Investigation·Manabu OhyamaJonathan C Vogel
Dec 23, 2006·The Journal of Investigative Dermatology·Yuriko ItoHitoshi Okochi
Mar 29, 2007·The Journal of Cell Biology·Nao OsakaHidenori Ichijo
Jun 8, 2007·Proceedings of the National Academy of Sciences of the United States of America·Krzysztof KobielakElaine Fuchs
Feb 5, 2008·Cell·Valerie HorsleyElaine Fuchs
Jun 11, 2008·Genesis : the Journal of Genetics and Development·Anna L MeansGuoqiang Gu
Oct 14, 2008·Nature Genetics·Viljar JaksRune Toftgård
Feb 10, 2009·Cell Stem Cell·Valentina GrecoElaine Fuchs
Jun 10, 2009·Laboratory Investigation; a Journal of Technical Methods and Pathology·Keita InoueKotaro Yoshimura
Dec 8, 2009·Journal of Dermatological Science·Chong Hyun WonKyu Han Kim
Mar 24, 2010·Molecular and Cellular Biology·Charlene S L HoiTudorita Tumbar
Apr 24, 2010·Developmental Cell·David Enshell-SeijffersBruce A Morgan
Aug 5, 2010·Cell Stem Cell·Ahmed MohyeldinAlfredo Quiñones-Hinojosa
Oct 20, 2010·Journal of Dermatological Science·Bo-Young YooJung-Keug Park
Feb 8, 2011·Cell Stem Cell·Shintaro TanimuraEmi K Nishimura
Mar 30, 2011·Journal of Cell Science·Ryan R DriskellFiona M Watt

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Citations

Jan 16, 2019·Expert Opinion on Investigational Drugs·Jorge Ocampo-GarzaAntonella Tosti
Jun 11, 2020·Tissue Engineering and Regenerative Medicine·Mohammad Ali NilforoushzadehEhsan Taghiabadi
Feb 14, 2020·Current Stem Cell Research & Therapy·Saba SameriRazieh Amini
Aug 10, 2020·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Young In LeeJu Hee Lee
Dec 5, 2020·Expert Review of Hematology·Shyla GuptaDiego Delgado
Nov 14, 2020·International Journal of Molecular Sciences·Antonio Martinez-LopezSalvador Arias-Santiago
Jun 17, 2020·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·R CarloniS Gandolfi

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BETA
biopsy

Software Mentioned

Rigenera

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