Therapeutic potential of targeting hydrogen peroxide metabolism in the treatment of brain ischaemia.

British Journal of Pharmacology
M ArmogidaNicola B Mercuri

Abstract

For many years after its discovery, hydrogen peroxide (H₂O₂) was viewed as a toxic molecule to human tissues; however, in light of recent findings, it is being recognized as an ubiquitous endogenous molecule of life as its biological role has been better elucidated. Indeed, increasing evidence suggests that H₂O₂ may act as a second messenger with a pro-survival role in several physiological processes. In addition, our group has recently demonstrated neuroprotective effects of H₂O₂ on in vitro and in vivo ischaemic models through a catalase (CAT) enzyme-mediated mechanism. Therefore, the present review summarizes experimental data supporting a neuroprotective potential of H₂O₂ in ischaemic stroke that has been principally achieved by means of pharmacological and genetic strategies that modify either the activity or the expression of the superoxide dismutase (SOD), glutathione peroxidase (GPx) and CAT enzymes, which are key regulators of H₂O₂ metabolism. It also critically discusses a translational impact concerning the role played by H₂O₂ in ischaemic stroke. Based on these data, we hope that further research will be done in order to better understand the mechanisms underlying H₂O₂ functions and to promote successful H₂O₂ signal...Continue Reading

References

Sep 1, 1978·Stroke; a Journal of Cerebral Circulation·E S FlammJ Ransohoff
Nov 1, 1992·Journal of Neurochemistry·B Halliwell
Oct 1, 1991·Journal of Applied Physiology·R J TraystmanR C Koehler
Feb 1, 1989·The American Journal of Physiology·T H LiuC Y Hsu
Jan 1, 1989·Free Radical Biology & Medicine·C A ColtonD Gilbert
Mar 15, 1967·Annals of the New York Academy of Sciences·J W FinneyJ T Mallams
Aug 1, 1968·European Journal of Biochemistry·K F Tipton
Dec 1, 1984·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·T YusaB A Freeman
May 1, 1982·Annals of Neurology·W A PulsinelliF Plum
Jan 1, 1995·Annual Review of Biochemistry·I Fridovich
Nov 17, 1994·Annals of the New York Academy of Sciences·G Cohen
Dec 1, 1993·Neurochemical Research·A VanellaJ R Perez-Polo
May 1, 1996·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·C K Sen, L Packer
Jan 16, 1998·European Journal of Pharmacology·H KatsukiN Matsuki
Apr 29, 1998·Brain Research. Molecular Brain Research·M Weisbrot-LefkowitzO Mirochnitchenko
Oct 10, 1998·Brain Research. Brain Research Protocols·B LeiT Arai
Jun 23, 1999·Progress in Neuro-psychopharmacology & Biological Psychiatry·E Klann, E Thiels
Oct 3, 1999·Physiological Reviews·P Lipton
Apr 12, 2000·Proceedings of the National Academy of Sciences of the United States of America·D FurlingG Massicotte
Jun 20, 2000·FEBS Letters·F Antunes, E Cadenas
Oct 31, 2000·Journal of the Neurological Sciences·B C WhiteG S Krause
Dec 8, 2000·FEBS Letters·B HalliwellL H Long
Jun 2, 2001·Journal of Neurophysiology·B T ChenM E Rice
Dec 26, 2001·Science's STKE : Signal Transduction Knowledge Environment·S G RheeJ Kwon
Feb 19, 2002·Neurochemistry International·Neil R Sims, Michelle F Anderson

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Citations

Sep 13, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Ivo JuránekAristidis M Tsatsakis
Nov 14, 2013·ACS Chemical Neuroscience·Marta LeirósLuis M Botana
Jul 31, 2013·Acta Pharmacologica Sinica·Fudong Liu, Louise D McCullough
Dec 7, 2013·PloS One·Teruya TamaruKen Takamatsu
Sep 21, 2013·Neuromolecular Medicine·Marco Feligioni, Robert Nisticò
Sep 10, 2014·International Journal of Molecular Sciences·Shu-Hui DaiXiao-Fan Jiang
Jun 30, 2015·Brain Research·Thiago Beltram MarcelinoCristiane Matté
Oct 31, 2014·Journal of Neuroscience Research·Michaela C HohnholtRalf Dringen
Jun 1, 2015·Free Radical Biology & Medicine·Artak TovmasyanInes Batinic-Haberle
Feb 15, 2014·Free Radical Biology & Medicine·Michaela C Hohnholt, Ralf Dringen
Jan 16, 2015·The Journal of Surgical Research·Tianlong HuangXuejun Sun
Mar 24, 2017·BMC Hematology·Lamis KaddamAmal M Saeed
May 16, 2018·Stroke; a Journal of Cerebral Circulation·Atsushi MizumaMidori A Yenari
Sep 8, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Balázs KripliJózsef Kaizer
Aug 26, 2014·Reviews in the Neurosciences·Lauren E Salminen, Robert H Paul
Aug 3, 2020·Journal of Cellular Physiology·Ardeshir AbbasiZuhair Mohammad Hassan
Jan 1, 2017·Archives of Virology·Fernanda Caetano CaminiCintia Lopes de Brito Magalhães
Aug 6, 2014·International Journal of Molecular Medicine·Shu-Hui DaiXiao-Fan Jiang
Jul 28, 2020·The American Journal of Medicine·Hussam AlhassonRichard Alweis
Apr 4, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mikhail G AkimovVladimir V Bezuglov
Jun 22, 2021·Frontiers in Immunology·Alexia Dumas, Ulla G Knaus
Nov 20, 2018·Inorganic Chemistry·Andrea LiberatoManuel G Basallote

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