Therapeutic potential of targeting kinase inhibition in patients with idiopathic pulmonary fibrosis

Yeungnam University Journal of Medicine
Suji KimChang-Hoon Woo

Abstract

Fibrosis is characterized by excessive accumulation of extracellular matrix components. The fibrotic process ultimately leads to organ dysfunction and failure in chronic inflammatory and metabolic diseases such as pulmonary fibrosis, advanced kidney disease, and liver cirrhosis. Idiopathic pulmonary fibrosis (IPF) is a common form of progressive and chronic interstitial lung disease of unknown etiology. Pathophysiologically, the parenchyma of the lung alveoli, interstitium, and capillary endothelium becomes scarred and stiff, which makes breathing difficult because the lungs have to work harder to transfer oxygen and carbon dioxide between the alveolar space and bloodstream. The transforming growth factor beta (TGF-) signaling pathway plays an important role in the pathogenesis of pulmonary fibrosis and scarring of the lung tissue. Recent clinical trials focused on the development of pharmacological agents that either directly or indirectly target kinases for the treatment of IPF. Therefore, to develop therapeutic targets for pulmonary fibrosis, it is essential to understand the key factors involved in the pathogenesis of pulmonary fibrosis and the underlying signaling pathway. The objective of this review is to discuss the ro...Continue Reading

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Citations

Sep 3, 2020·Yeungnam University Journal of Medicine·Jin Hong Chung

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Methods Mentioned

BETA
antisense oligonucleotides
nuclear translocation

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NCT02277145
NCT00532233
NCT00075998
NCT03502902
NCT01371305
NCT04396756
NCT03727802
NCT03832946
NCT03955146
NCT02688647

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