Therapeutic potential of yeast killer toxin-like antibodies and mimotopes

FEMS Yeast Research
Walter MaglianiLuciano Polonelli

Abstract

This review focuses on the potential of yeast killer toxin (KT)-like antibodies (KTAbs), that mimic a wide-spectrum KT through interaction with specific cell wall receptors (KTR) and their molecular derivatives (killer mimotopes), as putative new tools for transdisease anti-infective therapy. KTAbs are produced during the course of experimental and natural infections caused by KTR-bearing micro-organisms. They have been produced by idiotypic vaccination with a KT-neutralizing mAb, also in their monoclonal and recombinant formats. KTAbs and KTAbs-derived mimotopes may exert a strong therapeutic activity against mucosal and systemic infections caused by eukaryotic and prokaryotic pathogenic agents, thus representing new potential wide-spectrum antibiotics.

References

Jan 1, 1991·Journal of Medical and Veterinary Mycology : Bi-monthly Publication of the International Society for Human and Animal Mycology·L PolonelliC Chezzi
Feb 1, 1987·Journal of Clinical Microbiology·L Polonelli, G Morace
Mar 1, 1988·Journal of Clinical Microbiology·L Polonelli, G Morace
Sep 1, 1987·Canadian Journal of Microbiology·W T StarmerH J Phaff
Nov 1, 1986·Journal of Clinical Microbiology·L Polonelli, G Morace
Nov 1, 1986·Mycopathologia·L PolonelliG Morace
Dec 1, 1995·Gastroenterology·M Pettoello-MantovaniS Guandalini
Jan 1, 1993·Scandinavian Journal of Immunology·L PolonelliC Chezzi
Dec 29, 1995·The American Journal of Medicine·R C Moellering
Mar 1, 1997·Clinical and Diagnostic Laboratory Immunology·L PolonelliJ C Cailliez
Jul 1, 1997·Clinical Microbiology Reviews·W MaglianiL Polonelli
Mar 21, 1998·The Journal of Eukaryotic Microbiology·N SéguyJ C Cailliez
Jun 29, 2001·Transplant Infectious Disease : an Official Journal of the Transplantation Society·T J Walsh, A H Groll
Mar 7, 2002·International Reviews of Immunology·M R OggioniL Polonelli
Mar 7, 2002·Trends in Molecular Medicine·Walter MaglianiLuciano Polonelli
Jul 20, 2002·Current Opinion in Infectious Diseases·Ian M Gould
Aug 16, 2002·International Microbiology : the Official Journal of the Spanish Society for Microbiology·D MarquinaJ M Peinado
Aug 22, 2002·The Journal of Eukaryotic Microbiology·Dianella SavoiaLuciano Polonelli
Jan 8, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·David M Livermore
Jan 8, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Juergen Loeffler, David A Stevens
Jan 10, 2003·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·G C Schito
Jan 11, 2003·Biotechnology & Genetic Engineering Reviews·Walter MaglianiLuciano Polonelli
Apr 8, 2003·Current Pharmaceutical Biotechnology·W MaglianiL Polonelli
May 3, 2003·The Journal of Clinical Investigation·Franklin D Lowy
Jun 25, 2003·Antimicrobial Agents and Chemotherapy·Ruth C MatthewsJames Burnie
Jul 16, 2003·Current Opinion in Infectious Diseases·Rafael CantónFernando Baquero
Mar 26, 2004·Vaccine·Ruth C Matthews, James P Burnie
Sep 2, 2004·Cellular Microbiology·Elio CenciAnna Vecchiarelli

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Citations

Dec 20, 2007·Journal of Thrombosis and Haemostasis : JTH·F ScheiflingerR J Kerschbaumer
Oct 1, 2008·Antimicrobial Agents and Chemotherapy·Giorgio ContiLuciano Polonelli
Apr 27, 2011·Antimicrobial Agents and Chemotherapy·Sonia BrenaJosé Pontón
Aug 3, 2011·Future Medicinal Chemistry·Walter MaglianiLuciano Polonelli
Jan 1, 2015·Microorganisms·Serena Muccilli, Cristina Restuccia
Aug 12, 2009·Analytical Biochemistry·Senthilkumar KrishnaswamyTadazumi Komiyama
Sep 1, 2007·Microbiological Research·Sónia da SilvaCristina Aguiar
Sep 13, 2008·FEMS Microbiology Letters·Walter MaglianiLuciano Polonelli
Sep 2, 2009·Anais Da Academia Brasileira De Ciências·Elaine G RodriguesLuiz R Travassos
Feb 8, 2018·Brazilian Journal of Biology = Revista Brasleira De Biologia·E Robledo-LealC Rodriguez-Padilla
May 4, 2005·Yeast
Apr 11, 2020·FEMS Yeast Research·Bruna L NascimentoRinaldo F Gandra
Mar 24, 2017·Toxins·Ignacio BeldaAntonio Santos

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