PMID: 9541826May 9, 1998Paper

Therapeutic range of repetitive nanosecond laser exposures in selective RPE photocoagulation

Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie
Johann RoiderR Birngruber

Abstract

The aim of this study was to investigate whether selective damage the RPE while sparing the adjacent photoreceptors is possible with repetitive 200-ns pulses of Nd:YAG laser (532 nm) and what potential side effects can be expected with higher pulse energies. We irradiated the retinas of 19 eyes of 10 chinchilla rabbits with 500 pulses from a Nd:YAG laser, each 200 ns in duration, at a repetition rate of 500 Hz (158 microns, 0-120 microJ). Threshold curves for different effects were established. Representative lesions were investigated by light and transmission electron microscopy. It was possible to produce lesions, which were only visible by fluorescein angiography. The ED50 threshold energy per pulse for visibility by fluorescein angiography was 2.1 microJ per pulse, for visibility by ophthalmoscopy 8.6 microJ. Bubble formation, an uncommon phenomenon in retinal photocoagulation, occurred at energies of 15-25 microJ. Hemorrhage occurred at surprisingly high energy levels of more than 100 microJ. Histology performed on lesions visible only by angiography showed damage primarily to the RPE and outer segments, with very little damage to some inner segments dependent on the energy used. Selective RPE damage is possible with repet...Continue Reading

Citations

Apr 16, 2010·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Johann RoiderReginald Birngruber
Mar 15, 2006·The British Journal of Ophthalmology·T J DesmettreM A Mainster
Dec 28, 1999·The British Journal of Ophthalmology·J RoiderR Birngruber
Nov 22, 2007·Survey of Ophthalmology·Yaniv Barkana, Michael Belkin
Jul 16, 2011·Lasers in Surgery and Medicine·John P M WoodRobert J Casson
Apr 10, 2016·Clinical & Experimental Ophthalmology·Luke ChehadeRobert J Casson
Mar 17, 2004·Lasers in Surgery and Medicine·Carsten FrammeRalf Brinkmann
Jan 18, 2006·Journal of Biomedical Optics·Georg SchueleRalf Brinkmann
Apr 12, 2000·Seminars in Ophthalmology·M A Mainster
Oct 20, 2004·Seminars in Ophthalmology·M A Mainster, E Reichel
Jan 26, 2017·Vestnik oftalmologii·A V Bol'shunovS M Shmeleva
Nov 27, 2020·Experimental Eye Research·Yanxiu LiYannis M Paulus
Dec 7, 2007·Ophthalmic Surgery, Lasers & Imaging : the Official Journal of the International Society for Imaging in the Eye·Jorge ColomeEduardo Fernandez
Sep 21, 2010·Survey of Ophthalmology·Sobha SivaprasadGiorgio Dorin

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