Therapeutic regulation of complement in patients with renal disease - where is the promise?

Clinical Nephrology
Johua M Thurman

Abstract

Numerous renal diseases are characterized by complement activation within the kidney, and several lines of evidence implicate complement activation as an important part of the pathogenesis of these diseases. Investigators have long anticipated that complement inhibitors would be important and effective therapies for renal diseases. Eculizumab is a monoclonal antibody to the complement protein C5 that has now been administered to patients with several types of renal disease. The apparent efficacy of this agent may herald a new era in the treatment of renal disease, but many questions about the optimal use of therapeutic complement inhibitors remain. Herein we review the rationale for using complement inhibitors in patients with renal disease and discuss several drugs and approaches that are currently under development.

Citations

Apr 26, 2013·Kidney International·Takehiko Wada, Masaomi Nangaku
Oct 31, 2019·Renal Failure·Shani Zilberman-ItskovichShai Efrati
Dec 15, 2020·Jornal brasileiro de nefrologia : ʹorgão oficial de Sociedades Brasileira e Latino-Americana de Nefrologia·Luísa Pereira, Joana Marques
Jun 25, 2021·Curēus·Pooja Patel, Nino Balanchivadze

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Methods Mentioned

BETA
biopsy
biopsies

Clinical Trials Mentioned

NCT01221181

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