Therapeutic response to asthma medications: genotype predictors

Treatments in Respiratory Medicine
Alison M Wallace, Andrew J Sandford

Abstract

Asthma is a major social and economic burden. Studies have shown that genetic polymorphisms can influence drug efficacy and/or toxicity. The understanding of the pharmacogenetics of asthma will allow therapeutic regimens to be tailored on an individual basis. It is hoped that linkage and association studies will define new therapeutic targets for asthma but until then, studies have focused on improving response to beta(2)-adrenoceptor agonist and leukotriene modifier therapy. Genetic polymorphism may account for interindividual differences in toxicity and efficacy of asthma medications. To date, single nucleotide polymorphism and limited haplotype analysis have provided inconclusive evidence as to how genotype predictors can be used to optimize current asthma therapies based on each patient's genetic profile.

References

Dec 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·S HoshikoB Samuelsson
Jan 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·R A DixonC A Rouzer
Jul 1, 1995·American Journal of Respiratory Cell and Molecular Biology·S A GreenS B Liggett
Mar 1, 1993·American Journal of Respiratory Cell and Molecular Biology·E ReihsausS B Liggett
Aug 1, 1997·The Journal of Allergy and Clinical Immunology·J C DewarI P Hall
Oct 6, 1997·American Journal of Respiratory and Critical Care Medicine·D H SmithW B Saunders
Dec 31, 1997·American Journal of Respiratory and Critical Care Medicine
Aug 12, 1998·American Journal of Respiratory Cell and Molecular Biology·E S SilvermanT Collins
Sep 10, 1998·American Journal of Respiratory and Critical Care Medicine·T D WeirP D Paré
Nov 17, 1998·American Journal of Respiratory and Critical Care Medicine·M Johnson
Dec 3, 1998·The Journal of Clinical Investigation·D W McGrawS B Liggett
Dec 16, 1998·American Journal of Respiratory and Critical Care Medicine·M D'amatoP M Matricardi
May 4, 1999·International Archives of Allergy and Immunology·J M Drazen, E S Silverman
May 21, 1999·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·K A DeichmannJ Kuehr
May 26, 1999·Clinical Pharmacology and Therapeutics·J J LimaJ A Johnson
Sep 1, 1999·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·C E RamsayP N Lesouef
Oct 19, 1999·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Y KotaniM Yokoyama
Feb 12, 2000·Chest·B J Lipworth, C M Jackson
Feb 12, 2000·Chest·B J Lipworth
Mar 11, 2000·American Journal of Respiratory and Critical Care Medicine·A J Sandford, P D Paré
Jul 21, 2000·American Journal of Respiratory and Critical Care Medicine·E IsraelC N Yandava
Aug 10, 2000·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·J W HollowayR Beasley
Aug 26, 2000·Current Opinion in Chemical Biology·B Destenaves, F Thomas

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Citations

Sep 20, 2006·Pharmacogenomics·Pallav BhatnagarRitushree Kukreti
Jul 29, 2006·Pediatric Clinics of North America·John R MeurerHoward J Jacob

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