PMID: 7090634Jan 1, 1982Paper

Therapeutic results obtained from women with functional sterility. Second communication: clomiphene therapy (author's transl)

Zentralblatt für Gynäkologie
W WeiseP Prügel


Reported in this paper are results obtained from treatment of 246 patients for sterility in WHO Group II to whom clomiphene had been applied. Some of these patients had been earlier treated without success, using combined oestrogen-gestagen preparations. Primary sterility was manifest in 86 per cent of the cases, and biphasic cycle was recorded from 95 per cent of the probands.--The pregnancy rate was 30.1 per cent, but 22 per cent of pregnancies ended in abortion. Multiple pregnancy was observed in four per cent. Minor side effects occurred in 1.2 per cent of the cases.--Best results were 36 per cent in cases of secondary amenorrhoea and 32 per cent in cases of anovulation. Sixty-six per cent of all pregnancies occurred in the first three cycles of treatment. Eight per cent of the women grew pregnant six months within discontinuation of clomiphene medication. An unambiguous interdependence was found to exist between age of the patient, length over time of desire of children, and rate of conception. The pregnancy rate fell to 15 per cent in women beyond 30 years of age. A pregnancy rate of 35 per cent was achieved in 110 women in whom sterility had been solely caused by functional aspects, while 27 per cent were achieved for co...Continue Reading

Related Concepts

Abortion, Habitual
Subfertility, Female

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