PMID: 11902489Mar 21, 2002Paper

Therapeutic results of alternating chemoradiotherapy for nasopharyngeal cancer using cisplatin and 5-fluorouracil: its usefulness and controversial points

Japanese Journal of Clinical Oncology
Nobukazu FuwaK Morita

Abstract

The present study was conducted to evaluate the therapeutic results of alternating chemoradiotherapy for locally advanced nasopharyngeal cancer (NPC). The subjects consisted of six patients with stage III nasopharyngeal cancer and 26 patients with stage IV nasopharyngeal cancer. Using 6 MV photons, radiotherapy was performed at an exposure of 1.8-2.0 Gy five times per week. That is, a total absorbed dose of 36-40 Gy was irradiated between the base of the skull and supraclavicular fossa. After decreasing the irradiation field, an absorbed dose of 26-30 Gy was additionally given thereafter. One course of chemotherapy consisted of the administration of 5-fluorouracil (5-FU) at a dose of 700 mg/m2/24 h for 5 days (days 1-5) and cisplatin (CDDP) at a dose of 50 mg/m2/24 h for 2 days (days 6-7) and a total of 2-3 courses of chemotherapy were performed. During the alternating chemoradiotherapy, chemotherapy was performed initially and 3-5 days after completing the chemotherapy, radiotherapy was performed for 3-4 weeks. Thereafter, chemotherapy and radiotherapy were performed alternately. The scheduled courses of alternating chemoradiotherapy were completed in 30 (94%) of 32 patients. Although one patient developed shock induced by met...Continue Reading

Citations

Jul 3, 2008·The Journal of the American Dental Association·William James Maloney, Mea A Weinberg
Jan 15, 2015·Japanese Journal of Clinical Oncology·Tomokazu YoshizakiNaohiro Wakisaka
Jun 8, 2012·International Journal of Surgical Oncology·Dae Dong Kim, Cathy Eng
Mar 19, 2014·The Annals of Otology, Rhinology, and Laryngology·Takayoshi UenoTomokazu Yoshizaki

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