Therapeutic role of curcumin in oxidative DNA damage caused by formaldehyde

Microscopy Research and Technique
Gulay CiftciAli Ertekin

Abstract

Formaldehyde is a common environmental contaminant that causes oxidative DNA damage in cells by increasing the production of reactive oxygen species. The aim of this study was to investigate the amount of 8-hydroxy-deoxyguanosine (8-OhdG), tumor protein 53(TP53), beta-amyloid[Aß(1-42), Aß (1-40)], total antioxidant capacity (TAC) and malondialdehyde (MDA) and the therapeutic role of curcumin in rat cells with oxidative DNA damage caused by formaldehyde. The control group was given physiological saline for 15 days (i.p.) and the second group was given 37% formaldehyde (i.p.) at a dose of 9 mg/kg group every other day. The third group was given 9 mg/kg formaldehyde (i.p.) every other day and treated therapeutically with 100 mg/kg curcumin every day by gavage. At the end of the trial period, urine, blood, and brain tissue was collected from the rats. The levels of MDA in sera were increased and the TAC, TP53, and Aß (1-40) levels were reduced in the formaldehyde-treated group with respect to the control group (p<0.005). After treatment with curcumin, the levels of sera MDA were significantly reduced, the TAC, TP53, and Aß (1-40) levels were significantly increased (P < 0.05). The levels of whole brain Aß (1-42) and 8-OhdG were inc...Continue Reading

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Citations

Jun 28, 2016·Environmental Toxicology and Pharmacology·Huaxiao WenXianliang Wang
Oct 31, 2016·Asian Pacific Journal of Tropical Medicine·Tahereh FarkhondehFariborz Samini
Mar 28, 2019·Journal of Basic and Clinical Physiology and Pharmacology·Halef Okan Doğan, Mehmet Eray Alçiğir
Jul 1, 2020·International Journal of Molecular Sciences·Ekaterina ProshkinaAlexey Moskalev
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Dec 12, 2019·Environmental Science and Pollution Research International·Damla Arslan-Acaroz, Nalan Bayşu-Sozbilir
Aug 27, 2019·DNA Repair·Maryam MajidiniaBahman Yousefi
Apr 28, 2021·Regulatory Toxicology and Pharmacology : RTP·Akiyoshi NishikawaKumiko Ogawa
Jan 26, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Azar Hosseini, Hossein Hosseinzadeh

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