Therapeutic roles of telocytes in OVA-induced acute asthma in mice

Journal of Cellular and Molecular Medicine
Ling YeXiangdong Wang

Abstract

Telocytes (TCs) newly discovered as the mesenchyme-derived interstitial cells were found to have supportive effects on mesenchymal stem cells (MSCs). The present study aimed at investigating effects of TCs or TCs gathered with MSCs on experimental airway inflammation and hyper-responsiveness. The TCs were isolated from the lung tissue of the female BALB/c mice. The ovalbumin (OVA)-induced asthma model was established. TCs (1 × 106 /2 × 106 ) and/or MSCs (1 × 106 ) were injected through mice tail vein for consecutive three days before OVA excited the mice. This study at first demonstrated that the transplantation of TCs could improve allergen-induced asthma by obviously inhibiting airway inflammation and airway hyper-responsiveness preclinically, with the down-regulation of Th2-related cytokine IL-4, transcription factor GATA-3 and Th2 cell differentiation, while up-regulation of Th1-related cytokine IFN-γ, transcription factor T-bet and Th1 cells proliferation in asthma, just like MSCs. Co-transplantation of TCs with MSCs showed better therapeutic effects on experimental asthma, even though the therapeutic effects of TCs alone were similar to those of MSCs alone. TCs and the combination of TCs with MSCs could improve the airway...Continue Reading

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Citations

Jun 25, 2019·Journal of Cellular and Molecular Medicine·Shinan LiShaoheng He
Aug 24, 2019·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Mugurel C RusuDoina E Tofolean
May 17, 2019·Journal of Translational Medicine·Dongli SongXiangdong Wang
Aug 26, 2019·Allergology International : Official Journal of the Japanese Society of Allergology·He LiWenru Su
Apr 7, 2021·PloS One·Yasuhisa TamuraYosky Kataoka

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Methods Mentioned

BETA
lavage
flow cytometry
bronchoalveolar
ELISA
PCR

Software Mentioned

SPSS Statistics

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