Therapeutic significance of elevated tissue transglutaminase expression in pancreatic cancer.

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Amit VermaKapil Mehta

Abstract

Tissue transglutaminase (TG2) is a multifunctional protein that is implicated in development of drug resistance and metastasis. Therefore, we examined therapeutic targeting of TG2 for inhibiting growth and metastasis of in vivo growing pancreatic ductal adenocarcinoma (PDAC) in nude mice. We implanted Panc-28 pancreatic cancer cells to induce orthotopic PDAC tumors in nude mice and determined the efficacy of liposomal TG2 small interfering RNA (siRNA) either alone or in combination with gemcitabine. We show that down-regulation of endogenous TG2 by siRNA could effectively block the growth of PDAC. Moreover, down-regulation of TG2 significantly enhanced the therapeutic efficacy of gemcitabine against PDAC and inhibited metastatic spread of the disease. The antitumor activity was related to inhibition of proliferation, angiogenesis, and Akt phosphorylation. siRNA-mediated down-regulation of TG2 represents a promising therapeutic approach for improved treatment of PDAC.

References

Aug 1, 1994·International Journal of Cancer. Journal International Du Cancer·K Mehta
Feb 23, 2000·The Journal of Cell Biology·S S AkimovA M Belkin
Oct 9, 2002·Trends in Biochemical Sciences·Laszlo Fesus, Mauro Piacentini
Feb 4, 2003·Nature Reviews. Molecular Cell Biology·Laszlo Lorand, Robert M Graham
May 10, 2003·The Biochemical Journal·Go HasegawaYuji Saito
Sep 10, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Karkada MohanThomas B Issekutz
Feb 27, 2004·Investigative Ophthalmology & Visual Science·Siegfried G PriglingerUlrich Welge-Lussen
Dec 9, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Kapil MehtaAysegul A Sahin
Mar 5, 2005·Progress in Experimental Tumor Research·Kapil Mehta
Sep 9, 2005·Frontiers in Bioscience : a Journal and Virtual Library·Kapil MehtaLingegowda S Mangala
Nov 3, 2005·Nature Clinical Practice. Gastroenterology & Hepatology·Vivek Maheshwari, A James Moser
Mar 4, 2006·CA: a Cancer Journal for Clinicians·Ahmedin JemalMichael J Thun
Jul 5, 2006·Molecular Cancer Therapeutics·Jansina Y FokKapil Mehta
Aug 18, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jyotsnabaran HalderAnil K Sood
Mar 22, 2007·Molecular Cancer Research : MCR·Ugur AkarGabriel Lopez-Berestein
Jul 31, 2007·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Amit Verma, Kapil Mehta
Aug 3, 2007·Cancer Research·Minati SatpathyDaniela Matei
Apr 3, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Amit VermaKapil Mehta

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Citations

Aug 6, 2011·Amino Acids·Zhuo Wang, Martin Griffin
Dec 2, 2011·Amino Acids·Alfredo BudillonElena Di Gennaro
Dec 12, 2012·Breast Cancer Research and Treatment·Kevin D Brown
Jul 3, 2010·Journal of Neuro-oncology·Lisa M DyerKevin D Brown
Apr 24, 2009·The Journal of Biological Chemistry·Evgeny A ZemskovAlexey M Belkin
Oct 5, 2013·Journal of the National Cancer Institute·Dong Hoon ShinHo-Young Lee
May 6, 2010·Molecular Cancer Therapeutics·Kuzhuvelil B HarikumarSushovan Guha
May 16, 2013·Breast Cancer Research : BCR·Navneet AgnihotriKapil Mehta
Dec 21, 2013·Nanomedicine·Qiaoya LinGang Zheng
Apr 21, 2012·Future Oncology·Liquan Yang, Lei Xu
Apr 5, 2012·Nanomedicine·Serguei Vinogradov, Xin Wei
Apr 5, 2014·Drug Metabolism Reviews·Anamaria OrzaAlexandru Biris
Dec 30, 2014·Expert Opinion on Drug Delivery·Ana Tari Ashizawa, Jorge Cortes
Jan 31, 2014·International Journal of Cancer. Journal International Du Cancer·Santosh KumarKapil Mehta
Dec 25, 2009·Clinical and Experimental Immunology·A PekárikováL Tucková
Sep 3, 2010·Contrast Media & Molecular Imaging·Lorenzo TeiSilvio Aime
Nov 13, 2009·International Journal of Cancer. Journal International Du Cancer·Kuzhuvelil B HarikumarBharat B Aggarwal
Aug 11, 2015·Molecular Carcinogenesis·Richard L EckertCandace Kerr
Mar 31, 2015·Journal of Pathology and Translational Medicine·Min Jee ParkKyung Chul Moon
Jul 25, 2013·Advanced Drug Delivery Reviews·Arun K IyerMansoor M Amiji
Oct 15, 2013·Advanced Drug Delivery Reviews·Janet L MarkmanJulia Y Ljubimova
Sep 14, 2016·Virchows Archiv : an International Journal of Pathology·María Jesús Fernández-AceñeroJ Ignacio Casal
Oct 27, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Chengbo YuLanjuan Li
Oct 30, 2016·Neoplasia : an International Journal for Oncology Research·Jiyoon LeeDaniela Matei
Jan 30, 2019·Medical Sciences : Open Access Journal·Claudio TabolacciSimone Beninati
Feb 10, 2019·Medical Sciences : Open Access Journal·Ayca Ece NezirDilek Telci
Apr 3, 2014·Physiological Reviews·Richard L EckertKapil Mehta

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