Therapeutic strategies for atrial fibrillation. The value of decision analysis

Cardiology Clinics
M L GreenbergD L Disch

Abstract

In the absence of randomized, controlled trials of low-dose amiodarone in atrial fibrillation or a randomized, controlled trial of ventricular rate control versus antifibrillatory therapy, a Markov decision analysis is useful in comparing different therapeutic strategies for atrial fibrillation. The decision analysis described compared warfarin, quinidine, and low-dose amiodarone in patients with asymptomatic or minimally symptomatic chronic, persistent atrial fibrillation. This model suggests that electrical cardioversion followed by low-dose amiodarone is a relatively safe, effective alternative to long-term warfarin therapy.

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Citations

Nov 12, 2005·Medical Decision Making : an International Journal of the Society for Medical Decision Making·Nicky J Welton, A E Ades
Apr 21, 1999·Journal of Cardiovascular Electrophysiology·J M MillerJ E Olgin
Sep 4, 2004·PharmacoEconomics·M P TengD P Melby

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