Therapeutic Strategies for Mitigating Driving Risk in Patients with Narcolepsy

Therapeutics and Clinical Risk Management
Catherine A McCall, Nathaniel F Watson

Abstract

Narcolepsy is a central nervous system hypersomnia disorder characterized by uncontrollable episodes of daytime sleep, sleep state instability, and cataplexy (sudden loss of muscle tone precipitated by emotion). Individuals with narcolepsy report more frequent sleep-related crashes, near crashes, and drowsy driving than drivers with other sleep disorders. As such, evaluating risk of sleep-related crashes is of great importance for this patient population. There are no established guidelines for ensuring driving safety in patients with narcolepsy; however, many providers currently use a combination of subjective report, report of prior crashes or near-misses, report of previously falling asleep while driving, sleepiness screening tools, and maintenance of wakefulness testing (MWT) to determine risk. Driving simulator tests, though often unavailable to the clinician, provide data to support the use of MWT for evaluation of alertness in drivers with narcolepsy. Treatments such as modafinil may improve driving performance; however, the impact of other treatments such as stimulants and sodium oxybate on driving has not been extensively studied. Behavioral and lifestyle modifications may also reduce risk, including scheduled naps, dr...Continue Reading

References

Sep 1, 1981·Revue d'électroencéphalographie et de neurophysiologie clinique·V Valley, R Broughton
Nov 1, 1981·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·R BroughtonB Roth
Feb 1, 1993·Clinical Neuropharmacology·D B BoivinS Lubin
Jan 1, 1993·Neurophysiologie clinique = Clinical neurophysiology·C GuilleminaultA Clerk
Feb 1, 1993·Sleep·G K HenryR L Heilbronner
Feb 13, 1997·The New England Journal of Medicine·D A Redelmeier, R J Tibshirani
May 20, 1998·International Journal of Legal Medicine·L A Reyner, J A Horne
Jun 20, 1998·JAMA : the Journal of the American Medical Association·J M LyznickiM A Williams
Dec 1, 1995·Journal of Sleep Research·J A Horne, L A Reyner
Apr 17, 2003·Drugs & Aging·Sangeeta S Chakravorty, David B Rye
May 14, 2003·Forensic Science International : Synergy·Ingrid J Bosman, Klaas J Lusthof
Oct 4, 2003·Pharmacotherapy·David E Fuller, Carl S Hornfeldt
Aug 7, 2004·Clinical Neurology and Neurosurgery·Sylvia KotterbaMaritta Orth
Aug 20, 2004·American Journal of Respiratory and Critical Care Medicine·Mark E HowardRobert J Pierce
Sep 1, 2004·Sleep Medicine Reviews·William C HoughtonMichael Thorpy
Feb 11, 2005·Sleep·Michael R LittnerUNKNOWN Standards of Practice Committee of the American Academy of Sleep Medicine
Jan 13, 2006·JAMA : the Journal of the American Medical Association·Adam T WertzKenneth P Wright
Feb 22, 2007·Sleep·W T LongstrethGerald van Belle
Apr 12, 2007·Sleep·Nelson B PowellEdward M Weaver
Aug 19, 2010·European Journal of Clinical Pharmacology·Muhammad S Al-SamarraieMimi Stokke Opdal
Jun 17, 2011·Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine·Douglas McKay WallaceShirin Shafazand
Aug 16, 2012·Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine·Mashael K AlshaikhAhmed S BaHammam
Jun 4, 2013·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·Pierre PhilipAurore Capelli
Jan 13, 2015·Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine·Richard K BoganMaja Miloslavsky
Jun 9, 2015·PloS One·Fabio PizzaYves Dauvilliers
Dec 15, 2015·British Journal of Clinical Pharmacology·Matthias E LiechtiOliver G Bosch
Aug 6, 2017·Sleep Medicine Clinics·Shinichi Takenoshita, Seiji Nishino
Jan 26, 2018·Current Drug Metabolism·Carmela CentolaRaffaele Giorgetti
Sep 21, 2018·Psychopharmacology·Evangelia LiakoniNeal L Benowitz
Oct 26, 2018·Practical Neurology·Paul Reading
Feb 9, 2019·Sleep & Breathing = Schlaf & Atmung·David G IngramBaha Al-Shawwa

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Canadian Medical Association Journal
T J Murray
Deutsche medizinische Wochenschrift
K W Lange
European Neurology
Don Todman
Glasgow Medical Journal
T Kay Maclachlan
California and Western Medicine
S R Truman
© 2021 Meta ULC. All rights reserved