Therapeutic strategies for thrombosis: new targets and approaches

Nature Reviews. Drug Discovery
Nigel MackmanJeffrey I Weitz

Abstract

Antiplatelet agents and anticoagulants are a mainstay for the prevention and treatment of thrombosis. However, despite advances in antithrombotic therapy, a fundamental challenge is the side effect of bleeding. Improved understanding of the mechanisms of haemostasis and thrombosis has revealed new targets for attenuating thrombosis with the potential for less bleeding, including glycoprotein VI on platelets and factor XIa of the coagulation system. The efficacy and safety of new agents are currently being evaluated in phase III trials. This Review provides an overview of haemostasis and thrombosis, details the current landscape of antithrombotic agents, addresses challenges with preventing thromboembolic events in patients at high risk and describes the emerging therapeutic strategies that may break the inexorable link between antithrombotic therapy and bleeding risk.

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Methods Mentioned

BETA
amputation
amputations
protein folding
antisense oligonucleotides
genotyping

Clinical Trials Mentioned

NCT00526474
NCT00527943
NCT01000727
NCT00312052
NCT02157272
NCT02504216
NCT03735979
NCT02222714
NCT01806077
NCT02439190

Software Mentioned

CURE
FOXTROT
PLATO
Revacept
TRITON

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