Therapeutic Strategies to Treat Dry Eye in an Aging Population

Drugs & Aging
Nisreen S EzuddinAnat Galor

Abstract

Dry eye (DE) is a prevalent ocular disease that primarily affects the elderly. Affecting up to 30% of adults aged 50 years and older, DE affects both visual function and quality of life. Symptoms of DE, including ocular pain (aching, burning), visual disturbances, and tearing, can be addressed with therapeutic agents that target dysfunction of the meibomian glands, lacrimal glands, goblet cells, ocular surface, and/or neural network. This review provides an overview of the efficacy, use, and limitations of current therapeutic interventions being used to treat DE.

References

Mar 1, 1993·Current Eye Research·C K ChewA J Bron
Nov 1, 1995·Ophthalmic & Physiological Optics : the Journal of the British College of Ophthalmic Opticians (Optometrists)·J P CraigS Patel
Aug 8, 1998·Journal of the Autonomic Nervous System·C E DraperJ Singh
Sep 29, 2000·Cornea·S C PflugfelderM E Stern
Nov 22, 2001·JAMA : the Journal of the American Medical Association·D A SchaumbergM R Dana
Mar 14, 2003·Experimental Eye Research·W E ShineA G Pandya
Mar 18, 2003·Acupuncture & Electro-therapeutics Research·Johannes NeppAnna Spacek
Jul 23, 2003·Molecular and Cellular Biochemistry·Clare E DraperErnest Adeghate
Jul 31, 2003·American Journal of Ophthalmology·Debra A SchaumbergM Reza Dana
Oct 15, 2003·Archives of Ophthalmology·Jutta Horwath-WinterEva-Maria Haller-Schober
Mar 10, 2004·Archives of Ophthalmology·Scot E MossBarbara E K Klein
Apr 30, 2004·Acta Ophthalmologica Scandinavica·Marita Andersson GrönlundThomas Lundeberg
Aug 31, 2004·Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde·Anna M RoszkowskaSanto Galasso
Jan 25, 2005·The British Journal of Ophthalmology·S AokiH Tanaka
Jul 12, 2005·Current Medical Research and Opinion·Karl StonecipherDonna L Kerney
Jul 15, 2005·Cornea·Jay C ErieWilliam M Bourne
Mar 23, 2006·The American Journal of Chinese Medicine·Kuo-Lieh TsengJaung-Geng Lin
Apr 15, 2006·The British Journal of Ophthalmology·J D AronowiczJ P McCulley
Jan 12, 2007·The Ocular Surface·A J Bron, J M Tiffany
Mar 29, 2007·The British Journal of Ophthalmology·R L NiedererC N J McGhee
Feb 5, 2008·The British Journal of Ophthalmology·C E Pavesio, H H Decory
Feb 9, 2008·Drugs & Aging·Gary N Foulks
Sep 6, 2008·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Katherine M Mastrota
Oct 14, 2008·American Journal of Ophthalmology·Eun Chul KimChoun-Ki Joo
Dec 10, 2008·The Journal of Physiology·B NamerH O Handwerker
Feb 17, 2009·Investigative Ophthalmology & Visual Science·Hiroshi ToshidaAkira Murakami
Jun 10, 2009·Archives of Ophthalmology·Debra A SchaumbergDavid A Sullivan
Sep 8, 2009·Experimental Eye Research·Chyong Jy NienJames V Jester
Jan 26, 2010·Ophthalmology·Daniel G EzraRichard Collin
Feb 18, 2010·Ophthalmic Research·Douglas BorchmanEric Schwietz
Mar 27, 2010·Acta Ophthalmologica·Myeong Soo LeeEdzard Ernst
Apr 20, 2010·Molecular and Cellular Endocrinology·Agnes E Coutinho, Karen E Chapman
Apr 27, 2010·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Sanjay N Rao

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Citations

Nov 17, 2015·Current Opinion in Ophthalmology·Christine SutuNatalie A Afshari
Jun 11, 2016·Computers in Biology and Medicine·Robert KoprowskiEdward Wylęgała
Mar 24, 2017·Vox Sanguinis·D C MarksUNKNOWN Biomedical Excellence for Safer Transfusion (BEST) Collaborative
Jun 21, 2017·Clinical Anatomy : Official Journal of the American Association of Clinical Anatomists & the British Association of Clinical Anatomists·Joe IwanagaR Shane Tubbs
Mar 16, 2018·Vestnik oftalmologii·T N Safonova, N P Kintiukhina
Feb 2, 2018·Clinical Rheumatology·Matthew KoslowIssahar Ben-Dov
Aug 20, 2017·The British Journal of Ophthalmology·Erin S OngAnat Galor
Jun 28, 2017·BMC Ophthalmology·Jee Myung YangKyung Chul Yoon
Jun 26, 2017·Biomedical Engineering Online·Robert KoprowskiPaweł Olczyk

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