Therapeutic switching: from antidermatophytic essential oils to new leishmanicidal products

Memórias do Instituto Oswaldo Cruz
E HouëlD Stien

Abstract

This study examined whether the antidermatophytic activity of essential oils (EOs) can be used as an indicator for the discovery of active natural products against Leishmania amazonensis. The aerial parts of seven plants were hydrodistilled. Using broth microdilution techniques, the obtained EOs were tested against three strains of dermatophytes (Trichophyton mentagrophytes, Microsporum gypseum and Microsporum canis). To compare the EOs antifungal and antiparasitic effects, the EOs activities against axenic amastigotes of L. amazonensis were concurrently evaluated. For the most promising EOs, their antileishmanial activities against parasites infecting peritoneal macrophages of BALB/c mice were measured. The most interesting antifungal candidates were the EOs from Cymbopogon citratus, Otacanthus azureus and Protium heptaphyllum, whereas O. azureus, Piper hispidum and P. heptaphyllum EOs exhibited the lowest 50% inhibitory concentration (IC50) values against axenic amastigotes, thus revealing a certain correspondence between both activities. The P. hispidum EO was identified as the most promising product in the results from the infected macrophages model (IC50: 4.7 µg/mL, safety index: 8). The most abundant compounds found in th...Continue Reading

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Citations

Dec 16, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Karine Zanoli BernuciDiógenes Aparício Garcia Cortez
May 17, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Rosângela do Socorro Ferreira Rodrigues SarquisJosé Carlos Tavares Carvalho
Aug 4, 2020·Parasitology·Célia Eliane de Lara da SilvaMaria Valdrinez Campana Lonardoni
Apr 10, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Bahare SalehiWilliam N Setzer
Mar 19, 2019·Oxidative Medicine and Cellular Longevity·Emanuela Coutinho LunaFrancisco Jaime Bezerra Mendonça
Feb 9, 2017·Memórias do Instituto Oswaldo Cruz·Luz Helena VillamizarMaurilio José Soares
Dec 24, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Karine Zanoli BernuciDiógenes Aparício Garcia Cortez
May 23, 2020·Journal of Ethnopharmacology·Raissa Couto SantanaLucia H Pinto-da-Silva
May 5, 2021·Parasite : Journal De La Société Française De Parasitologie·Andrea DurofilTrinidad Ruiz-Téllez
Jul 11, 2021·Parasitology Research·Juliana Figueiredo PeixotoLuiz Filipe Gonçalves-Oliveira
Aug 29, 2021·Applied Microbiology and Biotechnology·Fillipe de Oliveira PereiraFrancinalva Dantas de Medeiros

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Methods Mentioned

BETA
NMR
FCS

Software Mentioned

Excel

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