Therapeutic targeting of chemokine interactions in atherosclerosis.

Nature Reviews. Drug Discovery
Rory R Koenen, Christian Weber

Abstract

Atherosclerosis is a chronic inflammatory disease of the arterial wall that is characterized by a disturbed equilibrium of immune responses and lipid accumulation, leading to the development of plaques. The atherogenic influx of mononuclear cells is orchestrated by chemokines and their receptors. Studies using gene-deficient mice and antagonists based on peptides and small molecules have generated insight into targeting chemokine-receptor axes for treating atherosclerosis, which might complement lipid-lowering strategies and risk factor modulation. Combined inhibition of multiple chemokine axes could interfere with the contributions of chemokines to disease progression at specific cells, stages or sites. In addition, the recently characterized heterophilic interactions of chemokines might present a novel target for the treatment and prevention of inflammatory diseases such as atherosclerosis.

References

Jan 1, 1995·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·G M Clore, A M Gronenborn
May 1, 1994·Current Biology : CB·D P Witt, A D Lander
Apr 1, 1994·Science·K RajarathnamI Clark-Lewis
Nov 14, 1997·Biochemistry·A J HoogewerfT N Wells
Aug 5, 1998·Proceedings of the National Academy of Sciences of the United States of America·Q MaT A Springer
Nov 5, 1999·The Journal of Biological Chemistry·A E ProudfootT N Wells
Jan 20, 2000·The New England Journal of Medicine·UNKNOWN Heart Outcomes Prevention Evaluation Study InvestigatorsG Dagenais
Dec 9, 2000·The Journal of Biological Chemistry·P LoetscherI Clark-Lewis
Dec 26, 2000·The Journal of Biological Chemistry·A E ProudfootT N Wells
Jan 4, 2001·Immunological Reviews·E BrandtH D Flad
Feb 7, 2002·Proceedings of the National Academy of Sciences of the United States of America·Hugues Lortat-JacobAnne Imberty
Jul 18, 2002·Nature Reviews. Drug Discovery·Matthias K Schwarz, Timothy N C Wells
Oct 9, 2002·The Journal of Experimental Medicine·Steffen MassbergMeinrad Gawaz
Nov 22, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Anne KrugMarco Colonna
Feb 7, 2003·Proceedings of the National Academy of Sciences of the United States of America·Amanda E I ProudfootMarie H Kosco-Vilbois
Oct 11, 2003·FEBS Letters·Bernard Degryse, Maddalena de Virgilio
Dec 5, 2003·Lancet·Michail S Lionakis, Dimitrios P Kontoyiannis
Dec 6, 2003·Circulation Research·Niels R VeillardFrançois Mach
Mar 5, 2004·JAMA : the Journal of the American Medical Association·Steven E NissenUNKNOWN REVERSAL Investigators
Mar 17, 2004·Current Opinion in Lipidology·Christina A BursillDavid R Greaves

❮ Previous
Next ❯

Citations

Jul 13, 2013·Inflammopharmacology·E Mendez-Enriquez, E A García-Zepeda
May 29, 2012·Current HIV/AIDS Reports·Markella V Zanni, Steven K Grinspoon
Jul 28, 2013·Immunobiology·Ioana Madalina Fenyo, Anca Violeta Gafencu
Nov 9, 2011·Nature Medicine·Christian Weber, Heidi Noels
Nov 26, 2011·Journal of Innate Immunity·Lorenza FrancescutCordula Stover
Oct 5, 2011·The Journal of Clinical Investigation·Christian Weber, Oliver Soehnlein
Feb 13, 2013·Mediators of Inflammation·Maria Chiara MaiuriPasquale Maffia
Apr 22, 2014·Trends in Endocrinology and Metabolism : TEM·Ismail Sergin, Babak Razani
Nov 1, 2011·EMBO Molecular Medicine·Rory R Koenen, Christian Weber
Mar 1, 2016·Frontiers in Immunology·Heidi Noels, Jürgen Bernhagen
Jun 16, 2012·Immunology Letters·Mieke GouwyMariagrazia Uguccioni
Dec 25, 2015·Journal of Clinical Lipidology·Terry A JacobsonUNKNOWN NLA Expert Panel
May 26, 2015·Cytokine & Growth Factor Reviews·Dipak P Ramji, Thomas S Davies
Nov 29, 2013·Thrombosis and Haemostasis·Ana Luíza Gomes QuinderéFabrizio Montecucco
Jun 10, 2011·Thrombosis and Haemostasis·Norbert GerdesNailin Li
Nov 14, 2014·Thrombosis and Haemostasis·D Sibbing, C Schulz
Aug 9, 2013·Thrombosis and Haemostasis·Birgit K KrampPhilipp von Hundelshausen
Oct 21, 2011·Thrombosis and Haemostasis·D Lievens, P von Hundelshausen
Nov 29, 2011·Molecular Nutrition & Food Research·Anthony Cam, Elvira Gonzalez de Mejia
Jul 16, 2010·Journal of Cellular and Molecular Medicine·Heather M Wilson
Dec 8, 2010·British Journal of Pharmacology·K L JonesA P Davenport
Feb 22, 2012·Journal of Cellular and Molecular Medicine·Ileana Manduteanu, Maya Simionescu
Sep 3, 2011·Cardiovascular Therapeutics·Mark D Huffman, Deepak Bhatnagar
Jul 2, 2010·Biopolymers·Pieter Van de VijverTilman M Hackeng
Jul 6, 2010·Archives of Biochemistry and Biophysics·Paola PalozzaAssunta Catalano
Dec 15, 2010·Experimental Cell Research·Birgit K KrampChristian Weber
Dec 18, 2010·Optics Express·Anusha PokhriyalBrian T Cunningham
Apr 20, 2016·Proceedings of the National Academy of Sciences of the United States of America·Wenguang G LiangWei-Jen Tang
Dec 15, 2010·Experimental Cell Research·Anneleen MortierPaul Proost
Aug 1, 2014·Seminars in Arthritis and Rheumatism·Jilke BeinsbergerJudith M E M Cosemans
Jun 27, 2014·Frontiers in Physiology·Yvonne DöringHeidi Noels
Jun 6, 2016·Immunology Letters·Tabish Qidwai
Jul 1, 2016·Future Medicinal Chemistry·Joe We Moss, Dipak P Ramji

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atherosclerosis Disease Progression

Atherosclerosis is the buildup of plaque on artery walls, causing stenosis which can eventually lead to clinically apparent cardiovascular disease. Find the latest research on atherosclerosis disease progression here.

Anti-Arrhythmic Drug Therapies

Anti-arrhythmic drugs are used to prevent abnormal heart rhythms. These medications are used in conditions including, ventricular tachycardia, ventricular fibrillation and atrial fibrillation. Discover the latest research on anti-arrhythmic drug therapies here.